SMI-4a

ALX-270-515

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Pim1 inhibitor

Selective inhibitor of Pim-1 and Pim-2 protein kinases. Inducer of G1 phase cell cycle arrest. Inducer of p27Kip1. Inducer of apoptosis through the mitocondrial pathway. Inhibitor of the mammalian target of rapamycin C1 (mTORC1) pathway. Downregulates c-myc. Inhibitor of PRAS40 phosphorylation and mTOR activity. Potential anti-cancer compound. Blocks prostate cancer growth.

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Product Details

Appearance	White to off-white solid.
CAS	327033-36-3
Couple Target	Pim
Couple Type	Inhibitor
Formula	C₁₁H₆F₃NO₂S
MW	273.2
Purity	≥95% (HPLC, TLC, NMR/ELSD)
Solubility	Soluble in DMSO (at least 5mg/ml).

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Stable for at least 6 months after receipt when stored at -20°C.
Handling	Protect from light.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

A small molecule inhibitor of Pim protein kinases blocks the growth of precursor T-cell lymphoblastic leukemia/lymphoma: Y.W. Lin, et al.; Blood 115, 824 (2010), Abstract
Regulation of Skp2 levels by the Pim-1 protein kinase: B. Cen, et al.; J. Biol. Chem. 285, 29128 (2010), Abstract — Full Text
Synthesis and evaluation of novel inhibitors of Pim-1 and Pim-2 protein kinases: Z. Xia, et al.; J. Med. Chem. 52, 74 (2009), Abstract
Novel benzylidene-thiazolidine-2,4-diones inhibit Pim protein kinase activity and induce cell cycle arrest in leukemia and prostate cancer cells: Z. Beharry, et al.; Mol. Cancer Ther. 8, 1473 (2009), Abstract — Full Text
PIM1 protein kinase regulates PRAS40 phosphorylation and mTOR activity in FDCP1 cells: F. Zhang, et al.; Cancer Biol. Ther. 8, 846 (2009), Abstract — Full Text

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SMI-4a

ALX-270-515

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

Certificate of Analysis

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