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Smac/DIABLO monoclonal antibody (79-1-83)

ADI-905-684

  • ADI-905-684-100   —   100 µg
    $319.00

Smac/DIABLO is one of the pro-apoptotic proteins normally found in the intermembrane space of the mitochondria. In response to apoptotic stimuli, Smac/DIABLO is released into the cytosol resulting in permeabilization of the mitochondrial membrane. Cytosolic Smac/DIABLO activates caspase-9 by binding IAP proteins. Changes in the expression level of Smac/DIABLO have been demonstrated in a number of human cancers including melanoma, ovary, and prostate.

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Regulatory Status

RUO – Research Use Only