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Pan-agonist of the estrogen receptor-related receptors with highest potency for ERRα. SLU-PP-332 increased mitochondrial function and cellular respiration in a skeletal muscle cell line. It also increased fast oxidative skeletal muscle fibers (Type IIa) and exercise endurance in mice in an ERRα-specific manner. SLU-PP-332 activates an acute aerobic exercise genetic response via inducing the expression of DDIT4.
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