SL-327

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MEK inhibitor

A selective inhibitor of MEK1 and MEK2 (IC₅₀= 0.18 and 0.22 µM respectively). Displays neuroprotective effects against ischemic brain injury.

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Alternative Name	[Amino[(4-aminophenyl)thio]methylene]-2-(trifluoromethyl)benzeneacetonitrile
Appearance	White to off-white solid.
CAS	305350-87-2
Couple Target	MEK
Couple Type	Inhibitor
Formula	C₁₆H₁₂F₃N₃S
MW	335.4
Purity	≥99% (HPLC)
Solubility	Soluble in DMSO to 100 mM or in ethanol to 100 mM.

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	-20°C
Shipping	Blue Ice

Regulatory Status	RUO – Research Use Only

Inhibition of extracellular signal-regulated kinase pathway suppresses tracheal stenosis in a novel mouse model: A. Kimura, et al.; PLoS One 169, e0256127 (2021), Abstract
Extracellular signal-regulated kinases 2 (Erk2) and Erk5 in the central nervous system differentially contribute to central sensitization in male mice: Matsuura, F., Satoh, Y., et al.; J. Neurosci. Res. 99, 1666 (2021), Abstract
Suppression of ERK phosphorylation through oxidative stress is involved in the mechanism underlying sevoflurane-induced toxicity in the developing brain: Yufune, S., Satoh, Y., et al.; Sci. Rep. 6, 21859 (2016), Abstract
Transient Blockade of ERK Phosphorylation in the Critical Period Causes Autistic Phenotypes as an Adult in Mice: Yufune, S., Satoh, Y., et al.; Sci. Rep. 5, 10252 (2015), Abstract
Pivotal role for ROS activation of p38 MAPK in the control of differentiation and tumor-initiating capacity of glioma-initiating cells: A. Sato, et al.; Stem Cell Res. 12, 119 (2014), Application(s): WB of human glioma-initiating cells, Abstract
Significant neuroprotection against ischemic brain injury by inhibition of the MEK1 protein kinase in mice: exploration of potential mechanism associated with apoptosis: X. Wang, et al.; J. Pharmacol. Exp. Ther. 304, 172 (2003), Abstract — Full Text
Regulation of cyclooxygenase-2 induction in the mouse uterus during decidualization. An event of early pregnancy: P. A. Scherle, et al.; J. Biol. Chem. 275, 37086 (2000), Abstract — Full Text

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