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SKL2001 is a Wnt/β-catenin pathway activator that disrupts the Axin/β-catenin interaction leading to β-catenin stabilization. It suppressed colon cancer spheroid growth via regulation of the E-cadherin/β-catenin complex. A commonly used reagent to reactivate or rescue the Wnt/β-Catenin signaling pathway.
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Last modified: January 24, 2025