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SK&F 96365

BML-CA230

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TRP channel blocker

A novel, selective inhibitor of receptor-mediated calcium entry. It inhibits receptor-mediated calcium entry in stimulated platelets (IC₅₀=8-12µM) neutrophils and endothelial cells at concentrations which do not affect internal Ca²⁺ release. Note, in some cells SK&F 96365 can activate a novel Ca²⁺ entry pathway. Blocks TRPC3 and TRPC6 activation. Inhibits the histamine-induced formation of nitric oxide in human endothelial cells.

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Product Details

Alternative Name	1-[β-[3-(4-Methoxyphenyl)propoxy]-4-methoxyphenethyl]-1H-imidazole . HCl, SKF-96365 . hydrochloride
Appearance	White solid.
CAS	130495-35-1
Couple Target	Calcium, TRP channel
Couple Type	Blocker
Formula	C₂₂H₂₆N₂O₃ . HCl
MW	402.9
MeltingPoint	117-119°C
Purity	≥98% (HPLC)
Solubility	Soluble in water (30mg/ml).

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Stable for at least 1 year after receipt when stored, as supplied, at room temperature. Stock solutions are stable for up to 3 months at -20°C.
Long Term Storage	Ambient
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Optopharmacological control of TRPC channels by coumarin-caged lipids is associated with a phototoxic membrane effect: O. Tiapko, et al.; Sci. China Life Sci. 59, 802 (2016), Application(s): Measurement of intracellular Ca2+ signaling, Abstract
Dual effects of SK&F 96365 in human leukemic HL-60 cells. Inhibition of calcium entry and activation of a novel cation influx pathway: Y.M. Leung, et al.; Biochem. Pharmacol. 51, 605 (1996), Abstract
Vectorial Ca2+ flux from the extracellular space to the endoplasmic reticulum via a restricted cytoplasmic compartment regulates inositol 1,4,5-trisphosphate-stimulated Ca2+ release from internal stores in vascular endothelial cells: O.A. Cabello, et al.; Biochem. J. 295, 357 (1993), Abstract
SK&F 96365 inhibits histamine-induced formation of endothelium-derived relaxing factor in human endothelial cells: W.F. Graier, et al.; Biochem. Biophys. Res. Commun. 186, 1539 (1992), Abstract
Inhibition of a receptor-operated calcium channel in pig aortic microsomes by cyclic GMP-dependent protein kinase: L.M. Blayney, et al.; Biochem. J. 273, 803 (1991), Abstract
SK&F 96365, a receptor-mediated calcium entry inhibitor, inhibits calcium responses to endothelin-1 in NG108-15 cells: J. Chan, et al.; Biochem. Biophys. Res. Commun. 177, 1141 (1991), Abstract
Receptor-mediated calcium influx in PC12 cells. ATP and bradykinin activate two independent pathways: C. Fasolato, et al.; J. Biol. Chem. 265, 20351 (1990), Abstract
SK&F 96365, a novel inhibitor of receptor-mediated calcium entry: J.E. Merritt, et al.; Biochem. J. 271, 515 (1990), Abstract

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SK&F 96365

BML-CA230

Product Details

Handling & Storage

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