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SKF-525A . HCl

BML-EI105

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Cytochrome P450 inhibitor

Cytochrome P-450 inhibitor. Inhibits cytochrome P-450-dependent arachidonate metabolism (90% at 50 µM). Calcium antagonist. Blocks glibenclamide-sensitive K+ channels (IC₅₀=4.4mM). Inhibits platelet thromboxane synthesis and stimulates endothelial cell prostacyclin production. Potentiates the effects of many drugs in vivo.

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Product Details

Alternative Name	Proadifen
Appearance	White to off-white solid.
CAS	62-68-0
Couple Target	Cytochrome P450, NOS, Potassium channel
Couple Type	Blocker, Inhibitor
Formula	C₂₃H₃₁NO₂ . HCl
Identity	Determined by 1H-NMR and MS.
MW	390.0
Purity	≥95% (TLC)
Solubility	Soluble in water (25mg/ml) or 100% ethanol.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Store, as supplied , at room temperature for up to 1 year.
Handling	Hygroscopic.
Long Term Storage	Ambient
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Subcellular localization and characterization of neuronal nitric oxide synthase: M. Hecker et al.; J. Neurochem. 62, 1524 (1994), Abstract
Inhibition by SKF 525A and quinacrine of endogenous glibenclamide-sensitive K+ channels in follicle-enclosed Xenopus oocytes: H. Sakuta & I. Yoneda; Eur. J. Pharmacol. 252, 117 (1994), Abstract
Inhibitors of cytochrome P-450 attenuate the myogenic response of dog renal arcuate arteries: K. Kauser et al.; Circ. Res. 68, 1154 (1991), Abstract
Effect of SKF 525A on the release of nitric oxide and prostacyclin from endothelial cells: D.D. Rees et al.; Eur. J. Pharmacol. 150, 149 (1988), Abstract
Stimulation of vascular prostacyclin by SKF 525-A (proadifen) and related compounds: J.M. Boeynaems et al.; Biochem. Pharmacol. 36, 1637 (1987), Abstract
Defining the active site of cytochrome P-450: the crystal and molecular structure of an inhibitor, SKF-525A: M. Rossi et al.; Carcinogenesis 8, 881 (1987), Abstract
Prostacyclin-stimulating drugs: new prospects: J.M. Boeynaems et al.; Prostaglandins 32, 145 (1986), Abstract
Cytochrome P450-dependent arachidonate metabolism in renomedullary cells: formation of Na+K+-ATPase inhibitor: M.A. Carroll et al.; J. Hypertens. Suppl. 4, S33 (1986), Abstract
Inhibition of mitochondrial oxidative metabolism by SKF-525A in intact cells and isolated mitochondria: T. Galeotti et al.; Biochem. Pharmacol. 32, 3285 (1983), Abstract
Stereoselective and calcium-dependent contractile effects of narcotic antagonist analgesics in the vascular smooth muscle of the rat: C.H. Lee & B.A. Berkowitz; J. Pharmacol. Exp. Ther. 198, 347 (1976), Abstract

Last modified: May 29, 2024

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SKF-525A . HCl

BML-EI105

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