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Sinefungin

ALX-380-070

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Methyltransferase inhibitor

Strong competitive inhibitor of methyltransferases which uses S-adenosyl-1-methionine as the methyl group donor to yield methylated products such as 5-methylcytosine or N⁶-methyl adenosine on DNA and RNA. In addition, sinefungin is involved in a number of physiological processes.

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Product Details

Alternative Name	6,9-Diamino-1-(6-amino-9H-purin-9-yl)-1,5,6,7,8,9-hexadeoxy-D-glycero-α-L-talo-decafuranuronic acid, A-9145, Adenosylornithine
Appearance	White to yellow powder.
CAS	58944-73-3
Couple Target	Methyltransferase
Couple Type	Inhibitor
Formula	C₁₅H₂₃N₇O₅
MI	14: 8544
MW	381.4
Purity	≥95% (HPLC)
RTECS	HE3140000
Solubility	Soluble in water.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Handling	Keep under nitrogen. Packaged under nitrogen. Protect from light. Very hygroscopic.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

A high-throughput screen for the identification of compounds that inhibit nematode gene expression by targeting spliced leader trans-splicing: Pandarakalam, G. C., Speake, M., et al.; Int. J. Parasitol. Drugs Drug Resist. 10, 28 (2019), Abstract
Miniaturization of High-Throughput Epigenetic Methyltransferase Assays with Acoustic Liquid Handling: Edwards, B., Lesnick, J., et al.; J. Lab. Autom. 21, 208 (2016), Abstract
Substrate binding in vitro and kinetics of RsrI [N6-adenine] DNA methyltransferase: S.S. Szegedi, et al.; Nucl. Acids Res. 28, 3962 (2000), Abstract
Identification of prenylcysteine carboxymethyltransferase in bovine adrenal chromaffin cells: H.M. De Busser, et al.; Int. J. Biochem. Cell Biol. 32, 1007 (2000), Abstract
The 2.2 A structure of the rRNA methyltransferase ErmC’ and its complexes with cofactor and cofactor analogs: implications for the reaction mechanism: G. Schluckebier, et al.; J. Mol. Biol. 289, 277 (1999), Abstract
Enzyme-mediated cytosine deamination by the bacterial methyltransferase M.MspI: J.M. Zingg, et al.; Biochem. J. 332, 223 (1998), Abstract
Two intertwined methylation activities of the MmeI restriction- modification class-IIS system from Methylophilus methylotrophus: J. Tucholski, et al.; Gene 223, 293 (1998), Abstract
Differential binding of S-adenosylmethionine S-adenosylhomocysteine and Sinefungin to the adenine-specific DNA methyltransferase M.TaqI: G. Schluckebier, et al.; J. Mol. Biol. 265, 56 (1997), Abstract
Effects of S-adenosylhomocysteine and analogs on Epstein-Barr virus- induced transformation, expression of the Epstein-Barr virus capsid antigen, and methylation of Epstein-Barr virus DNA: W.K. Long, et al.; J. Virol. 61, 221 (1987), Abstract
Sinefungin, a potent inhibitor or S-adenosylmethionine: protein O- methyltransferase: R.T. Borchardt, et al.; BBRC 89, 919 (1979), Abstract

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Sinefungin

ALX-380-070

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Handling & Storage

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