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Simvastatin

BML-G244

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HMG-CoA reductase inhibitor

HMG-CoA reductase inhibitor. Synthetic analog of Lovastatin (Prod. No. BML-G226). Inhibits the biosynthesis of isoprenoids and prevents small G protein activation. Displays lipid lowering and antihypertensive effects. Displays antiinflammatory, immunomodulatory effects as well as protective effects in experimental traumatic brain injury. Activates Rac1-dependent signalling pathway.

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Product Details

Appearance	White solid.
CAS	79902-63-9
Couple Target	HMG-CoA reductase
Couple Type	Inhibitor
Formula	C₂₅H₃₈O₅
MI	14: 8539
MW	418.6
Purity	≥98% (TLC)
RTECS	EK7798000
Solubility	Soluble in DMSO (>25mg/ml) or 100% ethanol (>25mg/ml); insoluble in water.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Stable for at least 1 year after receipt when stored, as supplied, at -20°C. Stock solutions are stable for up to 3 months at -20°C.
Long Term Storage	-20°C
Shipping	Blue Ice

Regulatory Status	RUO – Research Use Only

EmbryoNet: using deep learning to link embryonic phenotypes to signaling pathways: Čapek, D., Safroshkin, M., et al.; Nat. Methods 20, 815 (2023), Abstract
Simvastatin rescues memory and granule cell maturation through the Wnt/β-catenin signaling pathway in a mouse model of Alzheimer’s disease: X.K. Tong, et al.; Cell Death Dis. 13, 325 (2022), Abstract
Polycaprolactone-collagen nanofibers loaded with dexamethasone and simvastatin as an osteoinductive and immunocompatible scaffold for bone regeneration applications: H.A. Rather, et al.; Biomater. Biosyst. 8, 100064 (2022), Abstract
Pitavastatin Is a Highly Potent Inhibitor of T-Cell Proliferation: L. Voss, et al.; Pharmaceuticals (Basel) 14, 727 (2021), Abstract
Statin-induced metabolic reprogramming in head and neck cancer: a biomarker for targeting monocarboxylate transporters: M. Mehibel, et al.; Sci. Rep. 8, 16804 (2018), Abstract — Full Text
MyoScreen, a High-Throughput Phenotypic Screening Platform Enabling Muscle Drug Discovery: Young, J., Margaron, Y., et al.; SLAS Discov. 23, 790 (2018), Abstract
Simvastatin Enhances Activity and Trafficking of α7 Nicotinic Acetylcholine Receptor in Hippocampal Neurons Through PKC and CaMKII Signaling Pathways: Chen, T., Wang, Y., et al.; Front. Pharmacol. 9, 362 (2018), Abstract
Simvastatin prevents β-amyloid 25-35-impaired neurogenesis in hippocampal dentate gyrus through α7nAChR-dependent cascading PI3K-Akt and increasing BDNF via reduction of farnesyl pyrophosphate: C. Wang, et al.; Neuropharmacology 97, 122 (2015), Application(s): Oral administration to male mice, Abstract
Beyond lipid lowering: the anti-hypertensive role of statins: V. Chopra, et al.; Cardiovasc. Drugs Ther. 21, 161 (2007), Abstract
Simvastatin and atorvastatin improve behavioral outcome, reduce hippocampal degeneration, and improve cerebral blood flow after experimental traumatic brain injury: H. Wang, et al.; Exp. Neurol. 206, 59 (2007), Abstract

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Simvastatin

BML-G244

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