Shikonin

BML-CT115

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Inhibits angiogenesis

Shikonin inhibits TNF-α- and B6 melanoma-induced angiogenesis in mice. It blocks expression of integrin αvβ3 and inhibits endothelial cell proliferation and migration in vitro.

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Product Details

Appearance	Red crystalline solid.
CAS	517-89-5
Couple Target	CD51, CD61, Integrin
Couple Type	Inhibitor
Formula	C₁₆H₁₆O₅
Identity	Determined by NMR and MS.
MW	288.3
Purity	≥98% (HPLC)
Solubility	Soluble in DMSO.
Source	Shikonin is a napthoquinone isolated from the roots of Lithospermum erythrorhizon; a component of the traditional Chinese herbal remedy Shiunko.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	+4°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Neuronal autosis is Na+/K+-ATPase alpha 3-dependent and involved in hypoxic-ischemic neuronal death: Depierre, P., Ginet, V., et al.; Cell Death Dis. 15, 363 (2024), Abstract
Nephropreventive Effect of Shikonin on Murine LPS-induced Septic Acute Kidney: M. Kawara, et al.; J. Clin. Exp. Nephrol. 1, 19 (2016), Application(s): In vivo murine administration, Full Text
Cytotoxicity of natural products and derivatives towards MCF-7 cell monolayers and cancer stem-like mammospheres: E.J. Seo, et al.; Phytomedicine 22, 438 (2015), Application(s): Flow Cytometry, Abstract
Integration of Different -omics Technologies Identifies Inhibition of the IGF1R-Akt-mTOR Signaling Cascade Involved in the Cytotoxic Effect of Shikonin against Leukemia Cells: Wiench, B., Chen, Y. R., et al.; Evid. Based Complement. Alternat. Med. 2013, 818709 (2013), Abstract
Shikonin directly targets mitochondria and causes mitochondrial dysfunction in cancer cells: Wiench, B., Eichhorn, T., et al.; Evid. Based Complement. Alternat. Med. 2012, 726025 (2012), Abstract
A naphthoquinone derivative, shikonin, has insulin-like actions by inhibiting both phosphatase and tensin homolog deleted on chromosome 10 and tyrosine phosphatases: K. Nigorikawa, et al.; Mol. Pharmacol. 70, 1143 (2006), Abstract — Full Text
p53-mediated cell cycle arrest and apoptosis induced by shikonin via a caspase-9-dependent mechanism in human malignant melanoma A375-S2 cells: Z. Wu, et al.; J. Pharmacol. Sci. 94, 166 (2004), Abstract
Shikonin, an ingredient of Lithospermum erythrorhizon, inhibits angiogenesis in vivo and in vitro: T. Hisa, et al.; Anticancer Res. 18, 783 (1998), Abstract

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Shikonin

BML-CT115

Product Details

Handling & Storage

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