SH-5

ALX-270-349

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Akt inhibitor

Inhibitor of Akt (PKB) activation without affecting activation of the upstream kinase PDK-1, or other kinases downstream of Ras such as MAPK. Induces apoptosis and kills a variety of cancer cell lines containing high levels of active Akt and depending upon Akt for survival.

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Product Details

Alternative Name	D-3-Deoxy-2-O-methyl-myo-inositol 1-[(R)-2-methoxy-3-(octadecyloxy)propyl hydrogen phosphate]
Appearance	White to off-white solid.
Couple Target	Akt
Couple Type	Inhibitor
Formula	C₂₉H₅₉O₁₀P
Identity	Determined by 1H-NMR, 31P-NMR, 13C-NMR and MS.
MW	598.7
Purity	≥98% (TLC)
Solubility	Soluble in DMSO (10mg/ml) or methanol; slightly soluble in water.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	+4°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Carbon Monoxide Releasing Molecule-3 Enhances Heme Oxygenase-1 Induction via ROS-Dependent FoxO1 and Nrf2 in Brain Astrocytes: C. C. Lin, et al.; Oxid. Med. Cell. Longev. 2021, 5521196 (2021), Abstract
Molecular biological characteristics of the recruitment of hematopoietic stem cells from bone marrow niche in chronic myeloid leukemia: B. Zhu, et al.; Int. J. Clin. Exp. Pathol. 8, 12595 (2015), Application(s): Cell culture, Abstract — Full Text
New strategy for in vitro activation of primordial follicles with mTOR and PI3K stimulators: X. Sun, et al.; Cell Cycle 14, 721 (2015), Abstract — Full Text
Akt-dependent Pp2a activity is required for epidermal barrier formation during late embryonic development: O’Shaughnessy, R. F., Welti, J. C., et al.; Development 136, 3423 (2009), Abstract
Estrogen attenuates ischemic oxidative damage via an estrogen receptor alpha-mediated inhibition of NADPH oxidase activation: Zhang, Q. G., Raz, L., et al.; J. Neurosci. 29, 13823 (2009), Abstract
Carbon nanoparticle-induced lung epithelial cell proliferation is mediated by receptor-dependent Akt activation: Unfried, K., Sydlik, U., et al.; Am. J. Physiol. Lung Cell. Mol. Physiol. 294, L358 (2008), Abstract
Novel PI analogues selectively block activation of the pro-survival serine/threonine kinase, Akt.: A.P. Kozikowski, et al.; JACS 125, 1144 (2003), Abstract

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SH-5

ALX-270-349

Product Details

Handling & Storage

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