SEW-2871

BML-LP106

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S1P receptor ligand

SEW-2871 is a novel, potent EDG receptor agonist structurally unrelated to sphingosine-1-phosphate and is highly selective for the human S1P1 receptor. It inhibits lymphocyte recirculation in vivo and produces immunosuppression without associated bradycardia which is induced by other less selective S1P agonists. In mice SEW-2871 blocked TNFα induced monocyte adhesion to endothelium.

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Product Details

Alternative Name	5-[4-Phenyl-5-(trifluoromethyl)thiophen-2-yl]-3-[3-(trifluoromethyl)phenyl]-1,2,4-oxadiazole
Appearance	White solid.
CAS	256414-75-2
Couple Target	S1P receptor
Couple Type	Ligand
Formula	C₂₀H₁₀F₆N₂OS
MW	440.4
Purity	≥98%

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	Ambient
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

The Sphingosine 1-Phosphate Receptor Agonist FTY720 Potently Inhibits Regulatory T Cell Proliferation In Vitro and In Vivo: A.M. Wolf, et al.; J. Immunol. 183, 3751 (2009), Abstract
Sphingolipid signaling and treatment during remodeling of the uninfarcted ventricular wall after myocardial infarction.: C. C. Yeh, et al.; Am. J. Physiol. Heart Circ. Physiol. 296, H1193 (2009), Application(s): In vivo assays in mice, Abstract — Full Text
S1P(1)-selective agonist, SEW2871, ameliorates ischemic acute renal failure.: Y. H. Lien, et al.; Kidney Int. 69, 1601 (2006), Application(s): In vivo assays in mice, Abstract — Full Text
Sphingosine-1-phosphate prevents tumor necrosis factor-{alpha}-mediated monocyte adhesion to aortic endothelium in mice.: D. T. Bolick, et al.; Arterioscler. Thromb. Vasc. Biol. 25, 976 (2005), Application(s): In vivo assays in mice, Abstract — Full Text
Sphingosine 1-phosphate (S1P) receptor subtypes S1P1 and S1P3, respectively, regulate lymphocyte recirculation and heart rate.: M. G. Sanna, et al.; J. Biol. Chem. 279, 13839 (2004), Application(s): Calcium flux, kinase, cell migration and in vivo assays in mice, spleen cells, primary lymphocytes and CHO cells, Abstract — Full Text

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SEW-2871

BML-LP106

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