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SET07 is a histone methyltransferase that methylates Lys20 of histone H4, a specific tag for epigenetic transcriptional repression. The nuclear SET07 protein, which associates with silent chromatin on euchromatic arms but shows no association with constitutive heterochromatin, prefers nucleosomes as substrate compared to free histones. SET07 may play a role in maintaining silent chromatin by preventing neighboring acetylation of the H4 tail.
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Western blot analysis of SET07: Lane 1 – SAOS-2 Lane 2 – NIH/3T3 cell lysates.
| Regulatory Status |
RUO – Research Use Only |
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