Senescence Staining Assay

Cellular Senescence is the phenomenon wherein cells stop dividing. It can be induced by both internal (oxidative stress, DNA damage, etc.) and external (toxins, UV light, etc.) factors Senescence is a state of arrested growth in which cells remain viable but stop dividing. Senescent cells display increase of cell size, senescence-associated expression of β-galactosidase, p53 and P16 activity, along with altered patterns of gene expression. AkrivisBio’s Senescence Detection Kit is designed to detect β-Gal activity. β-Gal is present primarily in senescent cells but can give a false positive with cells that normally express β-gal such as mature macrophages.