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A selective inhibitor of p38α (IC50 = 3.2nM) and p38β (IC50 = 3.2nM), but not p38γ (IC50 > 50μM), ERK2, JNK1 or MAPKAP2. Lowers blood glucose and improves glucose homeostasis in nonobese diabetic mice. Enhances axonal regeneration in animals with nerve transection.
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Last modified: May 29, 2024