Scriptaid

BML-GR326

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HDAC inhibitor

Inhibitor of histone deacetylase (HDAC) (HDAC1 and 3: IC₅₀~0.6µM; HDAC8: IC₅₀~1µM) with lower toxicity than trichostatin A (Prod. No. BML-GR309). Inhibits tumor growth in vitro and in vivo and, in conjunction with 5-aza-2’-deoxycytidine (Prod. No. ALX-480-096), enhances expression of estrogen receptor α. Optimal concentration 2-2.5μg/ml (6-8μM). A negative control is available (Prod. No. BML-GR327).

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Product Details

Alternative Name	6-(1,3-Dioxo-1H,3H-benzo[de]isoquinolin-2-yl)-N-hydroxyhexanamide
Appearance	Yellow solid.
CAS	287383-59-9
Couple Target	HDAC, HDAC1, HDAC3, HDAC8
Couple Type	Inhibitor
Formula	C₁₈H₁₈N₂O₄
Identity	Determined by NMR.
MW	326.4
Purity	≥97% (HPLC)
Solubility	Soluble in DMSO (4mg/ml), ethanol (0.3mg/ml) or methanol.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Stable for at least 1 year after receipt when stored, as supplied, at -20°C. Stock solutions are stable for up to 3 months at -20°C.
Handling	Protect from air. Store under inert gas
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Ferroptosis in Neurons and Cancer Cells Is Similar But Differentially Regulated by Histone Deacetylase Inhibitors: M. Zille, et al.; eNeuro 6, ENEURO.0263-18.2019 (2019), Abstract — Full Text
Differential Regulation of Telomerase Reverse Transcriptase Promoter Activation and Protein Degradation by Histone Deacetylase Inhibition: Qing, H., Aono, J., et al.; J. Cell. Physiol. 231, 1276 (2016), Application(s): Cell Culture, Abstract
Histone hyperacetylation up-regulates protein kinase Cδ in dopaminergic neurons to induce cell death: relevance to epigenetic mechanisms of neurodegeneration in Parkinson disease: Jin, H., Kanthasamy, A., et al.; J. Biol. Chem. 289, 34743 (2014), Abstract
Inhibitors of histone deacetylases: correlation between isoform specificity and reactivation of HIV type 1 (HIV-1) from latently infected cells: K. Huber, et al.; J. Biol. Chem. 286, 22211 (2011), Abstract — Full Text
Epigenetic regulation of vascular smooth muscle cell proliferation and neointima formation by histone deacetylase inhibition: Findeisen, H. M., Gizard, F., et al.; Arterioscler. Thromb. Vasc. Biol. 31, 851 (2011), Abstract
Identification of novel isoform-selective inhibitors within class I histone deacetylases: E. Hu, et al.; J. Pharmacol. Exp. Ther. 307, 720 (2003), Abstract
A novel histone deacetylase inhibitor, scriptaid, enhances expression of functional estrogen receptor alpha (ER) in ER negative human breast cancer cells in combination with 5-aza 2′-deoxycytidine: J.C. Keen, et al.; Breast Cancer Res. Treat. 81, 177 (2003), Abstract
A novel histone deacetylase inhibitor identified by high-throughput transcriptional screening of a compound library: G.H. Su, et al.; Cancer Res. 60, 3137 (2000), Abstract — Full Text

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BML-GR326

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