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SCREEN-WELL^® REDOX library

BML-2835

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The SCREEN-WELL^® REDOX library contains 83 compounds with defined prooxidant or antioxidant activity. Compounds are dissolved in DMSO at 10mM and aliquoted into deep-well plates at 100 or 500µl per well.A variety of structurally and mechanistically different compound classes are included such as hydroperoxides, polyphenolics, metal chelators, thiols, thiol traps, radical scavengers, lazaroids and glutathione modulators as well as small molecule enzyme mimetics for SOD and glutathione peroxidase. The library is a useful tool for studying the roles of pro- and antioxidant molecules in cells as well as for use in in vitro applications.

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Application	HTS

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Stable for at least one year from the date of receipt when stored at -80°C.
Long Term Storage	-80°C
Shipping	Dry Ice

Regulatory Status	RUO – Research Use Only

Eugenol attenuates ischemia-mediated oxidative stress in cardiomyocytes via acetylation of histone at H3K27: P.K. Randhawa, et al.; Free Radic. Biol. Med. 194, 326 (2023), Abstract
A small molecule inhibitor of caspase-1 inhibits NLRP3 inflammasome activation and pyroptosis to alleviate gouty inflammation: D.Y. Cao, et al.; Immunol. Lett. 244, 28 (2022), Abstract
A novel NRF2/ARE inhibitor gossypol induces cytotoxicity and sensitizes chemotherapy responses in chemo-refractory cancer cells: Y.C. Tang, et al.; J. Food Drug Anal. 29, 638 (2021), Abstract
Drug screening with zebrafish visual behavior identifies carvedilol as a potential treatment for retinitis pigmentosa: L. Ganzen, et al.; Sci. Rep. 11, 11432 (2021), Abstract — Full Text
Small-Molecule Screens Reveal Novel Haustorium Inhibitors in the Root Parasitic Plant Triphysaria versicolor: Y. Wang, et al.; Phytopathology 109, 1878 (2019), Abstract — Full Text
Inhibitors of the protein disulfide isomerase family for the treatment of multiple myeloma: R.M. Robinson, et al.; Leukemia 33, 1011 (2019), Abstract — Full Text
Larval Zebrafish Lateral Line as a Model for Acoustic Trauma: P. Uribe, et al.; eNeuro 5, ENEURO.0206-18.2018 (2018), Abstract — Full Text
Identification and characterization of compounds that affect stomatal movements: S. Toh, et al.; Plant Cell Physiol. 59, 1568 (2018), Abstract
Screening antioxidants for the protection of cochlear sensory cells: D.G. Hur, et al.; Neural Regen. Res. 13, 62 (2018), Abstract — Full Text
An antioxidant screen identifies candidates for protection of cochlear hair cells from gentamicin toxicity: V. Noack, et al.; Front. Cell. Neurosci. 11, 242 (2017), Abstract — Full Text

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SCREEN-WELL^® REDOX library

BML-2835

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

Certificate of Analysis

SDS

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