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SCREEN-WELL^® Phosphatase Inhibitor library

BML-2834

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The SCREEN-WELL^® Phosphatase Inhibitor Library contains 33 known phosphatase inhibitors of well-defined activity. Inhibitors are supplied dissolved in DMSO at 10 mM and aliquoted into deep-well plates at either 100 µl or 500 µl per well. The library is ideal for chemical genomics, assay development, and as a reference set for secondary screening. Includes inhibitors of these important phosphatases: Calcineurin(PP2B), JSP-1, PRL-1, CD45, PP1, PRL-3, CDC25, PP2A, PTEN, and many more.

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Application	HTS

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Stable for at least one year from the date of receipt when stored at -80°C.
Long Term Storage	-80°C
Shipping	Dry Ice

Regulatory Status	RUO – Research Use Only

Phosphatase inhibitors BVT-948 and alexidine dihydrochloride inhibit sexual development of the malaria parasite Plasmodium berghei: X. Jia, et al.; Int. J. Parasitol. Drugs Drug Resist. 19, 81 (2022), Abstract — Full Text
Discovery of uncompetitive inhibitors of SapM that compromise intracellular survival of Mycobacterium tuberculosis: P.F. Soto, et al.; Sci. Rep. 11, 7667 (2021), Abstract — Full Text
Image-based high-throughput mapping of TGF-β-induced phosphocomplexes at a single-cell level: P. Lönn, et al.; Commun. Biol. 4, 1284 (2021), Abstract
Eukaryotic phosphatase inhibitors enhance colistin efficacy in gram‐negative bacteria: W.T. Barker, et al.; Chem. Biol. Drug Des. 96, 1180 (2020), Abstract — Full Text
PRL3-DDX21 Transcriptional Control of Endolysosomal Genes Restricts Melanocyte Stem Cell Differentiation: Johansson, J. A., Marie, K. L., et al.; Dev. Cell 54, 317 (2020), Abstract
Plasmodium berghei serine/threonine protein phosphatase PP5 plays a critical role in male gamete fertility: X. Zhu, et al.; Int. J. Parasitol. 49, 685 (2019), Abstract — Full Text
BML-265 and tyrphostin AG1478 disperse the Golgi apparatus and abolish protein transport in human cells: G. Boncompain, et al.; Front. Cell. Dev. Biol. 7, 232 (2019), Abstract — Full Text
Therapeutic Chemical Screen Identifies Phosphatase Inhibitors to Reconstitute PKB Phosphorylation and Cardiac Contractility in ILK-Deficient Zebrafish: A. Pott, et al.; Biomolecules 8, 153 (2018), Abstract
Macrolides selectively inhibit mutant KCNJ5 potassium channels that cause aldosterone-producing adenoma: U.I. Scholl, et al.; J. Clin. Invest. 127, 2739 (2017), Abstract — Full Text
Sorafenib tosylate inhibits directly necrosome complex formation and protects in mouse models of inflammation and tissue injury: S. Martens, et al.; Cell Death Dis. 8, e2904 (2017), Abstract — Full Text

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SCREEN-WELL^® Phosphatase Inhibitor library

BML-2834

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

Certificate of Analysis

SDS

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