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Natural products are an unsurpassed source of chemical diversity and an ideal starting point for any screening program for pharmacologically active small molecules. Historically, natural products have been the most successful source of new drugs. The SCREEN-WELL® Natural Product library offers over 500 isolated natural compounds of known structure and includes many compounds from ethnopharmacology. Compounds are provided in solution in DMSO. Individual compounds or subsets can be resupplied in gram quantities.
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Product Details
| Application |
HTS |
|---|---|
| Concentration |
2mg/ml in DMSO |
| Contents |
502 compounds including compounds from the following classes of products: Terpenoids, Peptolides, Flavones, Coumarins, Alkaloids, Macrolides, Isoflavones, Synthetic derivates and many more. |
| Quantity |
500µl/well |
Handling & Storage
| Use/Stability |
As indicated on product label or CoA when stored as recommended. Stable for at least one year from the date of receipt when stored at -80°C. |
|---|---|
| Long Term Storage |
-80°C |
| Shipping |
Dry Ice |
| Regulatory Status |
RUO – Research Use Only |
|---|
- A Low Concentration of Citreoviridin Prevents Both Intracellular Calcium Deposition in Vascular Smooth Muscle Cell and Osteoclast Activation In Vitro: S. Jeong, et al.; Molecules 28, 1693 (2023), Abstract
- Chelerythrine chloride inhibits Zika virus infection by targeting the viral NS4B protein: M.W.C. Loe, et al.; Antiviral Res. 219, 105732 (2023), Abstract
- Chelerythrine, a novel small molecule targeting IL-2, inhibits melanoma progression by blocking the interaction between IL-2 and its receptor: O. Cho, et al.; Life Sci. 320, 121559 (2023), Abstract
- The host-targeting compound peruvoside has a broad-spectrum antiviral activity against positive-sense RNA viruses: K.X. Wu, et al.; Acta Pharm. Sin. B 13, 2039 (2023), Abstract
- Deadenylase-dependent mRNA decay of GDF15 and FGF21 orchestrates food intake and energy expenditure: Katsumura, S., Siddiqui, N., et al.; Cell Metab. 34, 564 (2022), Abstract
- Phytochemical Characterization and Bioactivity Toward Breast Cancer Cells of Unhydrolyzed and Acid-Hydrolyzed Extracts of Fagonia indica: C.L. Miranda, et al.; Nat. Prod. Commun. 17, 10.1177 (2022), Abstract
- Computation-Assisted Identification of Bioactive Compounds in Botanical Extracts: A Case Study of Anti-Inflammatory Natural Products from Hops: K.S. Brown, et al.; Antioxidants 11, 1400 (2022), Abstract
- Phytochemical Investigation and Reproductive Capacity of the Bulgarian Endemic Plant Species Marrubium friwaldskyanum Boiss. (Lamiaceae): V.D. Zheljazkov, et al.; Plants (Basel) 11, 114 (2022), Abstract
- Chromatin remodeller CHD7 is required for GABAergic neuron development by promoting PAQR3 expression: P. Jamadagni, et al.; EMBO Rep. 15252, 50958 (2021), Abstract
- Pharmacologically targetable vulnerability in prostate cancer carrying RB1-SUCLA2 deletion: S. Kohno, et al.; Oncogene 39, 5690 (2020), Abstract
- Reporter Replicons for Antiviral Drug Discovery against Positive Single-Stranded RNA Viruses: R.S. Fernandes, et al.; Viruses 12, 598 (2020), Application(s): Evaluation of antiviral activity of the compounds, Abstract — Full Text
- A genetics-free method for high-throughput discovery of cryptic microbial metabolites: F. Xu, et al.; Nat. Chem. Biol. 15, 161 (2019), Abstract — Full Text
- Identification and characterization of Cardiac Glycosides as senolytic compounds: F. Triana-Martinez, et al.; Nat. Commun. 10, 4731 (2019), Abstract — Full Text
- Xenopus: An alternative model system for identifying muco-active agents.: H.J. Sim, et al.; PLoS One 2, e0193310 (2018), Abstract — Full Text
- Natural Compounds as Occult Ototoxins? Ginkgo biloba Flavonoids Moderately Damage Lateral Line Hair Cells: S. Neveux, et al.; J. Assoc. Rec. Otolaryngol. 18, 275 (2018), Abstract — Full Text
- A Novel Class of Natural FXR Modulators with a Unique Mode of Selective Co-regulator Assembly: W. Zheng, et al.; Chembiochem 18, 721 (2017), Application(s): AlphaScreen assay using LBD) of FXR as bait , Abstract
- Screening for small molecule inhibitors of statin-induced APP C-terminal toxic fragment production: K.S. Poksay, et al.; Front. Pharmacol. 8, 46 (2017), Abstract — Full Text
- Antiviral screen identifies EV71 inhibitors and reveals camptothecin-target, DNA topoisomerase 1 as a novel EV71 host factor: K.X. Wu & J.J. Chu; Antiviral Res. 143, 122 (2017), Abstract
- Cyclopiazonic acid, an inhibitor of calcium-dependent ATPases with antiviral activity against human respiratory syncytial virus: R. Cui, et al.; Antiviral Res. 132, 38 (2016), Abstract
- Targeting human respiratory syncytial virus transcription anti-termination factor M2-1 to inhibit in vivo viral replication: B. Bailly, et al.; Sci. Rep. 6, 25806 (2016), Application(s): Cell culture, Abstract — Full Text
- Development of a Cell-Based Fluorescence Polarization Biosensor Using Preproinsulin to Identify Compounds That Alter Insulin Granule Dynamics: N.Y. Yi, et al.; Assay Drug Dev. Technol. 13, 558 (2015), Abstract — Full Text
- Biphasic Effects of Ingenol 3,20-Dibenzoate on the Erythropoietin Receptor: Synergism at Low Doses and Antagonism at High Doses: J.G. Oh, et al.; Mol. Pharmacol. 88, 392 (2015), Abstract — Full Text
- Phenotypic screening identifies protein synthesis inhibitors as H-ras-nanocluster increasing tumor growth inducers: A.K. Najumudeen, et al.; Biochemistry 54, 7212 (2015), Application(s): Chemical screening with H-ras-NANOPS, Abstract
- High-throughput screen of natural product libraries for hsp90 inhibitors: J. Davenport, et al.; Biology (Basel) 3, 101 (2014), Application(s): HTS for HSP90 inhibitors, Abstract — Full Text
- Activity-based assay for human mono-ADP-ribosyltransferases ARTD7/PARP15 and ARTD10/PARP10 aimed at screening and profiling inhibitors: H. Venkannagari, et al.; Eur. J. Pharm. Sci. 49, 148 (2013), Abstract
- Inhibition of Chikungunya Virus Replication by Harringtonine, a Novel Antiviral That Suppresses Viral Protein Expression: P. Kaur, et al.; Antimicrob. Agents Chemother. 57, 155 (2013), Abstract — Full Text
- Natural compounds inhibiting the replication of Porcine reproductive and respiratory syndrome virus: A.K. Karuppannan, et al.; Antiviral Res. 94, 188 (2012), Abstract
- Gambogic acid, a natural product inhibitor of Hsp90: J. Davenport, et al.; J. Nat. Prod. 74, 1085 (2011), Abstract
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