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The ICCB Known Bioactives Library is an important product for use in chemical genetics and drug discovery. The library is a collection of 472 diverse biologically active compounds with defined biological activity and was developed in collaboration with the Harvard Institute of Chemistry and Cell Biology. It includes the following classes of compounds: GPCR ligands, Second messenger modulators, Nuclear receptor ligands, Actin & tubulin modulators, Kinase inhibitors, Protease inhibitors, Ion channel blockers, Gene regulation agents, Lipid biosynthesis inhibitors, many other classes. Each compound is supplied dissolved in DMSO at 100µL and is ready for assaying. The library can be used for assay development and validation, mechanism profiling, lead screening or as a reference library.
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Product Details
| Application |
HTS |
|---|---|
| Concentration |
DMSO solutions (concentration vary by compound and are provided in the documentation) |
| Contents |
472 compounds. Includes compounds that affect most cellular processes and drug target classes, including: GPCR ligands, Second messenger modulators, Nuclear receptor ligands, Actin and tubulin modulators, Kinase inhibitors, Protease inhibitors, Ion channel blockers, Gene regulation agents, Lipid biosynthesis inhibitors, Phosphodiesterase inhibitors, and many other classes. |
| Quantity |
100µl per well |
Handling & Storage
| Use/Stability |
As indicated on product label or CoA when stored as recommended. Stable for at least one year from the date of receipt when stored at -80°C. |
|---|---|
| Long Term Storage |
-80°C |
| Shipping |
Dry Ice |
| Regulatory Status |
RUO – Research Use Only |
|---|
- A high-throughput and low-waste viability assay for microbes: Meyer, C. T., Lynch, G. K., et al.; Nat. Microbiol. 8, 2304 (2023), Abstract
- High Throughput Viability Assay for Microbiology: Meyer, C. T., Lynch, G. K., et al.; bioRxiv , (2023)
- Deadenylase-dependent mRNA decay of GDF15 and FGF21 orchestrates food intake and energy expenditure: S. Katsumura, et al.; Cell Metab. 34, 564 (2022), Abstract
- The use of informer sets in screening: perspectives on an efficient strategy to identify new probes: P.A. Clemons, et al.; SLAS Discov. 26, 855 (2021), Abstract — Full Text
- Academic collaborative models fostering the translation of physiological in vitro systems from basic research into drug discovery: A. Silvestri, et al.; Drug Discov. Today 26, 1369 (2021), Abstract
- Induced pluripotent stem cell-derived monocytic cell lines from a NOMID patient serve as a screening platform for modulating NLRP3 inflammasome activity: R. Seki, et al.; PLoS One 15, e0237030 (2020), Abstract — Full Text
- NF-κB Signaling Negatively Regulates Osteoblast Dedifferentiation during Zebrafish Bone Regeneration: R. Mishra, et al.; Dev. Cell 52, 167 (2020), Application(s): Screening on Juvenile and adult zebrafish, Abstract
- Calcineurin phosphatase activity regulates Varicella-Zoster Virus induced cell-cell fusion: M. Zhou, et al.; PLoS Pathog. 16, e1009022 (2020), Application(s): Screening on transfected CHO-DSP1 cells, Abstract — Full Text
- Mechanisms of Nephrogenesis Revealed by Zebrafish Chemical Screen: Prostaglandin Signaling Modulates Nephron Progenitor Fate: B.E. Chambers, et al.; Nephron 143, 68 (2019), Abstract — Full Text
- Prostaglandin signaling regulates renal multiciliated cell specification and maturation: A.N. Marra, et al.; PNAS 116, 8409 (2019), Abstract — Full Text
- Discovery of Novel Therapeutics for Muscular Dystrophies using Zebrafish Phenotypic Screens: J.J. Widrick, et al.; J. Neuromuscul. Dis. 6, 271 (2019), Application(s): Screening on dystrophic zebrafish embryos or larvae, Abstract — Full Text
- Entosis and apical cell extrusion constitute a tumor-suppressive mechanism downstream of Matriptase: J. Armistead, et al.; J. Cell Bio. 219, e201905190 (2019), Application(s): Screening on zebrafish embryos, Abstract — Full Text
- High-Throughput Screening of Entamoeba Identifies Compounds Which Target Both Life Cycle Stages and Which Are Effective Against Metronidazole Resistant Parasites: G.M. Ehrenkaufer, et al.; Front. Cell. Infect. Microbiol. 8, 276 (2018), Abstract — Full Text
- Medium throughput biochemical compound screening identifies novel agents for pharmacotherapy of neurofibromatosis type 1: G. Semenova, et al.; Biochimie 135, 1 (2017), Abstract — Full Text
- Identification of antipsychotic drug fluspirilene as a potential anti-glioma stem cell drug: Y. Dong, et al.; Oncotarget 8, 111728 (2017), Abstract — Full Text
- Molecular Phenotyping Combines Molecular Information, Biological Relevance, and Patient Data to Improve Productivity of Early Drug Discovery: Drawnel, F. M., Zhang, J. D., et al.; Cell Chem. Biol. 24, 624 (2017), Abstract
- Therapeutic strategy for targeting aggressive malignant gliomas by disrupting their energy balance: A.M. Hegazy, et al.; J. Biol. Chem. 291, 21496 (2016), Abstract — Full Text
- A dual-targeting approach to inhibit Brucella abortus replication in human cells: D.M. Czyz, et al.; Sci. Rep. 6, 35835 (2016), Application(s): Identification of ICCB compounds that inhibit B. abortus metabolism in axenic culture, Abstract — Full Text
- Epoxyeicosatrienoic acids enhance embryonic haematopoiesis and adult marrow engraftment: P. Li, et al.; Nature 523, 468 (2015), Application(s): Adult zebrafish transplantation-based chemical screen, Abstract
- A novel 3D high-content assay identifies compounds that prevent fibroblast invasion into tissue surrogates: C. Wenzel, et al.; Exp. Cell. Res. 339, 35 (2015), Abstract
- High-throughput platform for the discovery of elicitors of silent bacterial gene clusters: M.R. Seyedsayamdost; Proc. Natl. Acad. Sci. 111, 7266 (2014), Application(s): Screening of strains of B. thailandensis E264, Abstract — Full Text
- High-Throughput Fluorimetric Assay for 2-Hydroxyglutarate Identifies Zaprinast as a Glutaminase Inhibitor: A. Elhammali, et al.; Cancer Discov. 4, 828 (2014), Abstract
- Retinoic acid isomers facilitate apolipoprotein E production and lipidation in astrocytes through the retinoid X receptor/retinoic acid receptor pathway: J. Zhou, et al.; J. Biol. Chem. 289, 11282 (2014), Application(s): Screening of immortalized apoE3 astrocytes, Abstract
- 3D high-content screening for the identification of compounds that target cells in dormant tumor spheroid regions: C. Wenzel, et al.; Exp. Cell Res. 323, 131 (2014), Abstract
- A novel four-step system for screening angiogenesis inhibitors: Q. Zhou, et al.; Mol. Med. Rep. 8, 1734 (2013), Application(s): Injection, Abstract — Full Text
- High-Throughput Screening of Small Molecules Identifies Hepcidin Antagonists: E. Fung, et al.; Mol. Pharmacol. 83, 681 (2013), Abstract — Full Text
- Chemical modulation of memory formation in larval zebrafish: M.A. Wolman, et al.; Proc. Natl. Acad. Sci. 108, 15468 (2011), Application(s): Screening of zebrafish larvae in pharmacologic experiments, Abstract — Full Text
- Image-based screening identifies novel roles for IkappaB kinase and glycogen synthase kinase 3 in axonal degenerationand Glycogen Synthase Kinase 3 in Axonal Degeneration: J. Gerdts, et al.; J. Biol. Chem. 286, 28011 (2011), Application(s): Screening for delay axon degeneration following axotomy, Abstract — Full Text
- Disease allele-dependent small-molecule sensitivities in blood cells from monogenic diabetes: S.Y. Shaw et al.; Proc. Natl. Acad. Sci. USA 108, 492 (2011), Abstract
- High-content chemical and RNAi screens for suppressors of neurotoxicity in a Huntington’s disease model: J. Schulte et al.; PLoS One 6, e23841 (2011), Abstract
- Chemical genetics reveals bacterial and host cell functions critical for type IV effector translocation by Legionella pneumophila: X. Charpentier et al.; PLoS Pathog. 5, e1000501 (2009), Abstract
- Identification of AML1-ETO modulators by chemical genomics: S.M. Corsello; Blood 113, 6193 (2009), Abstract
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