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SCREEN-WELL^® Epigenetics library

BML-2836

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The SCREEN-WELL^® Epigenetics library contains 43 compounds with defined activity against enzymes which carry out epigenetic modification of lysine. It also includes DNA methylation inhibitors. Compounds are dissolved in DMSO at 10mM and aliquoted into deep-well plates at 100 or 500µl per well. The library is a useful tool for chemical genomics, assay development and other pharmacological applications. The library contains inhibitors of these important enzymes: HDACs, SIRTs, Lysine demethylases, HATs, Histone methyl transferases, DNA methyltransferases as well as SIRT activators. A variety of structurally and mechanistically different compound classes are included.

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SCREEN-WELL® Epigenetics library hdac_graphs — Download our Application Note: A Flexible and Robust Solution for Automated 384-well HDAC Profiling.”””

Product Details

Application	HTS
Application Notes	Useful tool for chemical genomics, assay development, or other pharmacological applications in the study of epigenetic modifications of lysine and DNA methylation.
Contents	43 compounds supplied in DMSO at a concentration of 10mM.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Stable for at least one year from the date of receipt when stored at -80°C.
Long Term Storage	-80°C
Shipping	Dry Ice

Regulatory Status	RUO – Research Use Only

Memory of stochastic single-cell apoptotic signaling promotes chemoresistance in neuroblastoma: J.F. Hastings, et al.; Sci. Adv. 9, eabp8314 (2023), Abstract
Inhibition of Class I Histone Deacetylase Enhances Self-Reprogramming of Spermatogonial Stem Cells into Pluripotent Stem Cells: Y. Lee, et al.; Int. J. Stem Cells 16, 27 (2023), Abstract
High-Throughput Drug Library Screening in Primary KMT2A-Rearranged Infant ALL Cells Favors the Identification of Drug Candidates That Activate P53 Signaling: P. Wander, et al.; Biomedicines 10, 638 (2022), Abstract
RNA sequencing-based screen for reactivation of silenced alleles of autosomal genes: S. Gupta, et al.; G3 (Bethesda) 12, jkab428 (2022), Abstract
High-throughput drug screening reveals Pyrvinium pamoate as effective candidate against pediatric MLL-rearranged acute myeloid leukemia: P. Wander, et al.; Transl. Oncol. 14, 101048 (2021), Abstract
High-throughput screening identifies idasanutlin as a resensitizing drug for venetoclax-resistant neuroblastoma cells: L. Vernooij, et al.; Mol. Cancer Ther. 20, 1161 (2021), Abstract — Full Text
Integration of epigenetic mechanisms into non-genotoxic carcinogenicity hazard assessment: focus on DNA methylation and histone modifications: D. Desaulniers, et al.; Int. J. Mol. Sci. 22, 10969 (2021), Abstract — Full Text
Selective inhibition of HDAC6 regulates expression of the oncogenic driver EWSR1-FLI1 through the EWSR1 promoter in Ewing sarcoma: D.J. Garcia-Dominguez, et al.; Oncogene 40, 5843 (2021), Abstract — Full Text
Nullscript inhibits Cryptosporidium and Toxoplasma growth: F. Murakoshi, et al.; Int. J. Parasitol. Drugs Drug Resist. 14, 159 (2020), Abstract — Full Text
Decitabine mildly attenuates MLL‐rearranged acute lymphoblastic leukemia in vivo, and represents a poor chemo‐sensitizer: P. Schneider, et al.; EJHaem. 1, 527 (2020), Abstract — Full Text

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SCREEN-WELL^® Epigenetics library

BML-2836

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

Certificate of Analysis

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