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Structurally and mechanistically different compounds for studying the roles of pro- and anti-autophagic molecules in cells and in vitro applications.
The SCREEN-WELL® Autophagy library contains 94 compounds with defined autophagy-inducing or -inhibitory activity. Compounds are dissolved in DMSO or water at 10mM and aliquoted into deep-well plates at 100 or 500µl per well. A variety of structurally and mechanistically different compound classes are included. A useful tool for studying the roles of pro- and anti-autophagic molecules in cells as well as for use in in vitro applications.
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Product Details
| Application |
HTS |
|---|---|
| Concentration |
10 mM* in DMSO***Compounds are predominantly at concentration of 10mM unless otherwise stated.**Compounds are predominantly provided in DMSO. Selected compounds are dissolved in nuclease-free water. |
| Contents |
94 compounds with defined autophagy-inducing or -inhibitory activity. A variety of structurally and mechanistically different compound classes are included. |
| Quantity |
100 µl/well or 500 µl/well |
| Technical Info / Product Notes |
Application Note: Cell-Based Screening of Focused Bioactive Compound Libraries: Assessing Small Molecule Modulators of the Canonical Wnt Signaling and Autophagy-Lysosome Pathways. |
Handling & Storage
| Use/Stability |
As indicated on product label or CoA when stored as recommended. Stable for at least one year from the date of receipt when stored at -80°C. |
|---|---|
| Handling |
Avoid freeze/thaw cycles. |
| Long Term Storage |
-80°C |
| Shipping |
Dry Ice |
| Regulatory Status |
RUO – Research Use Only |
|---|
- Autophagy induction by piplartine ameliorates axonal degeneration caused by mutant HSPB1 and HSPB8 in charcot-marie-tooth type 2 neuropathies: A. Sisto, et al.; Autophagy , (2024), Abstract
- Licochalcone A regulates viral IRES activity to inhibit enterovirus replication: Y.T. Chuang, et al.; Antiviral Res. 221, 105755 (2024), Abstract
- Evaluation of Broad Anti-Coronavirus Activity of Autophagy-Related Compounds Using Human Airway Organoids: R. Hashimoto, et al.; Mol. Pharm. 20, 2276 (2023), Abstract
- FUCCI-based live imaging platform reveals cell cycle dynamics and identifies pro-proliferative compounds in human iPSC-derived cardiomyocytes: F. Murganti, et al.; Front. Cardiovasc. Med. 9, 840147 (2022), Abstract — Full Text
- C9orf72 ALS/FTD dipeptide repeat protein levels are reduced by small molecules that inhibit PKA or enhance protein degradation: N.V. Licata, et al.; EMBO J. 41, e105026 (2022), Abstract — Full Text
- Rescue of lysosomal function as therapeutic strategy for SPG15 hereditary spastic paraplegia: C. Vantaggiato, et al.; Brain , (2022), Abstract
- Metformin rescues muscle function in BAG3 myofibrillar myopathy models: A.A. Ruparelia, et al.; Autophagy 17, 2494 (2021), Abstract — Full Text
- Autophagy activation, lipotoxicity and lysosomal membrane permeabilization synergize to promote pimozide- and loperamide-induced glioma cell death: N. Meyer, et al.; Autophagy 17, 3424 (2021), Abstract — Full Text
- Role of ceramide/sphingomyelin (SM) balance regulated through “SM cycle” in cancer: M. Taniguchi, et al.; Cell Signal. 87, 110119 (2021), Abstract
- Repurposing diphenylbutylpiperidine-class antipsychotic drugs for host-directed therapy of Mycobacterium tuberculosis and Salmonella enterica infections: M.T. Heemskerk, et al.; Sci. Rep. 11, 19634 (2021), Abstract — Full Text
- Cell death-inducing cytotoxicity in truncated KCNQ4 variants associated with DFNA2 hearing loss: T. Kojima, et al.; Dis. Model. Mech. 14, dmm049015 (2021), Abstract — Full Text
- Phosphorylation of Eukaryotic Initiation factor-2α (eIF2α) in Autophagy: J. Humeau, et al.; Cell Death Dis. 11, 433 (2020), Abstract — Full Text
- Chemical screening approaches enabling drug discovery of autophagy modulators for biomedical applications in human diseases: P.K. Panda, et al.; Front. Cell. Dev. Biol. 7, 38 (2019), Abstract — Full Text
- Trans-Fats Inhibit Autophagy Induced by Saturated Fatty Acids: A. Sauvet, et al.; EBioMedicine 30, 261-272 (2018), Abstract
- Loperamide, pimozide, and STF-62247 trigger autophagy-dependent cell death in glioblastoma cells: S. Zielke, et al.; Cell Death Dis. 9, 994 (2018), Abstract — Full Text
- Evaluation of autophagy inducers in epithelial cells carrying the ΔF508 mutation of the cystic fibrosis transmembrane conductance regulator CFTR: S. Zhang, et al.; Cell Death Dis. 9, 191 (2018), Abstract — Full Text
- The Oxysterol 7-Ketocholesterol Reduces Zika Virus Titers in Vero Cells and Human Neurons: K.A. Willard, et al.; Viruses 11, 20 (2018), Application(s): Vero and C6/36 cells , Abstract — Full Text
- A novel cellular spheroid-based autophagy screen applying live fluorescence microscopy identifies nonactin as a strong inducer of autophagosomal turnover: F. Pampaloni, et al.; SLAS Discov. 22, 558 (2017), Abstract
- Identification of HSP90 inhibitors as a novel class of senolytics: H. Fuhrmann-Stroissnigg, et al.; Nat. Commun. 8, 422 (2017), Abstract
- Screening for small molecule inhibitors of statin-induced APP C-terminal toxic fragment production: K.S. Poksay, et al.; Front. Pharmacol. 8, 46 (2017), Abstract — Full Text
- Sorafenib tosylate inhibits directly necrosome complex formation and protects in mouse models of inflammation and tissue injury: S. Martens, et al.; Cell Death Dis. 8, e2904 (2017), Abstract — Full Text
- ICG-001 affects DRP1 activity and ER stress correlative with its anti-proliferative effect: H. Zinecker, et al.; Oncotarget. 8, 106764 (2017), Abstract — Full Text
- Trehalose upregulates progranulin expression in human and mouse models of GRN haploinsufficiency: a novel therapeutic lead to treat frontotemporal dementia: C.J. Holler, et al.; Mol. Neurodegener. 11, 46 (2016), Abstract — Full Text
- An inverse small molecule screen to design a chemically defined medium supporting long-term growth of Drosophila cell lines: M. Burnette, et al.; Mol. Biosyst. 10, 2713 (2014), Abstract — Full Text
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