SC-560

ALX-270-427

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COX inhibitor

Selective COX-1 inhibitor (IC₅₀=9nM). Shows 700-fold more selectivity over COX-2 (IC₅₀=6.3µM). Inhibits COX-1-derived platelet thromboxane B₂, gastric PGE₂, and dermal PGE₂ production. Orally active in rat.

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Product Details

Alternative Name	5-(4-Chlorophenyl)-1-(4-methoxyphenyl)-3-(trifluoromethyl)-1H-pyrazole
Appearance	White to off-white crystalline solid.
CAS	188817-13-2
Couple Target	COX
Couple Type	Inhibitor
Formula	C₁₇H₁₂N₂OClF₃
MW	352.7
Purity	≥98%
Solubility	Soluble in 100% ethanol, DMSO or dimethyl formamide; sparingly soluble in aqueous buffers.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Stable for at least 2 years after receipt when stored at –20°C.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Prostaglandin E2-mediated attenuation of mesocortical dopaminergic pathway is critical for susceptibility to repeated social defeat stress in mice: Tanaka, K., Furuyashiki, T., et al.; J. Neurosci. 32, 4319 (2012), Abstract
Prostaglandin E2-prostaglandin E receptor subtype 4 (EP4) signaling mediates UV irradiation-induced systemic immunosuppression: K. Soontrapa, et al.; PNAS U.S.A. 108, 6668 (2011), Abstract — Full Text
Combined effects of cyclooxygenase-1 and cyclooxygenase-2 selective inhibitors on ovarian carcinoma in vivo: W. Li, et al.; Int. J. Mol. Sci. 12, 668 (2011), Abstract — Full Text
Pharmacological analysis of cyclooxygenase-1 in inflammation: C.J. Smith, et al.; PNAS 95, 13313 (1998), Abstract — Full Text
Selective inhibition of inducible cyclooxygenase 2 in vivo is antiinflammatory and nonulcerogenic: J.L. Masferrer, et al.; PNAS 91, 3228 (1994), Abstract — Full Text

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SC-560

ALX-270-427

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

Certificate of Analysis

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