SC-514

BML-EI343

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IKK inhibitor

Selective, reversible and ATP-competitive inhibitor of IKK2 (IC₅₀=11.2µM). Does not inhibit other IKK isoforms or other serine/threonine or tyrosine kinases. Inhibits transcription of NF-κB dependent genes in IL-1β-induced rheumatoid arthritis-derived synovial fibroblasts in a dose-dependent fashion.

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Product Details

Appearance	Yellow solid.
CAS	354812-17-2
Couple Target	IKK, NF-kappaB
Couple Type	Inhibitor
Formula	C₉H₈N₂OS₂
MW	224.3
Purity	≥98% (TLC)
Solubility	Soluble in DMSO (>25mg/ml)

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Handling	If resuspended in solution, store at -20°C.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Pharmacological inhibition of mTORC1 increases CCKBR-specific tumor uptake of radiolabeled minigastrin analogue [ 177 Lu]Lu-PP-F11N: M. Grzmil, et al.; Theranostics 10, 10861 (2020), Abstract — Full Text
Regulators of thymic stromal lymphopoietin production by human adipocytes: L. Ma, et al.; Cytokine 136, 155284 (2020), Application(s): Treatment of preadipocytes in culture supernatant, Abstract
Thyroid-Stimulating Hormone-Stimulated Human Adipocytes Express Thymic Stromal Lymphopoietin: L. Ma, et al.; Horm. Metab. Res. 50, 325 (2018), Application(s): Treatment of Stromal preadipocytes in culture, Abstract
Intermittent hypoxia-induced NF-κB and HO-1 regulation in human endothelial EA.hy926 cells: Q. Han, et al.; Cell Biochem. Biophys. 66, 431 (2013), Application(s): Treatment of human endothelial EA.hy926 cell culture, Abstract
Involvement of metabotropic glutamate receptor 5, AKT/PI3K signaling and NF-kappaB pathway in methamphetamine-mediated increase in IL-6 and IL-8 expression in astrocytes: A. Shah, et al.; J. Neuroinflammation 9, 52 (2012), Abstract
A selective IKK-2 inhibitor blocks NF-kappa B-dependent gene expression in interleukin-1 beta-stimulated synovial fibroblasts: N. Kishore, et al.; J. Biol. Chem. 278, 32861 (2003), Abstract

Last modified: May 29, 2024

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SC-514

BML-EI343

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