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SB202190 . hydrochloride

ALX-270-268

10 citations

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p38 inhibitor

A water soluble form of the potent p38 (SAPK2a) inhibitor SB202190 (Prod. No. BML-EI294).

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Product Details

Alternative Name	FHPI . HCl, 4-(4-Fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)-1H-imidazole . HCl
Appearance	Yellow solid.
CAS	350228-36-3
Couple Target	p38
Couple Type	Inhibitor
Formula	C₂₀H₁₄FN₃O . HCl
Identity	Determined by 1H-NMR.
MW	331.3 . 36.5
Purity	≥96% (HPLC)
Solubility	Soluble in water, methanol or DMSO.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Handling	Protect from light.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

A secreted helminth microRNA suppresses gastrointestinal cell differentiation required for innate immunity: Pérez, M. G., Gillan, V., et al.; Front. Immunol. 16, 1558132 (2025), Abstract
Characterization of bovine and ovine basal-out and apical-out ileum organoids: Chapuis, A. F., Harte, T., et al.; R. Soc. Open Sci. 12, 250326 (2025), Abstract
Expression and functional characterization of bovine receptor activator of NF-κB ligand (RANKL): A.F. Chapuis, et al.; Vet. Immunol. Immunopathol. 268, 110705 (2024), Abstract
A secreted helminth microRNA suppresses gastrointestinal cell differentiation required for innate immunity: Perez, M. G., Gillan, V., et al.; bioRxiv , (2024)
Establishment of bovine 3D enteroid-derived 2D monolayers: K.M. Sutton, et al.; Vet. Res. 53, 15 (2022), Abstract
Development of Bovine Gastric Organoids as a Novel In Vitro Model to Study Host-Parasite Interactions in Gastrointestinal Nematode Infections: Faber, M. N., Smith, D., et al.; Front. Cell. Infect. Microbiol. 12, 904606 (2022), Abstract
The Development of Ovine Gastric and Intestinal Organoids for Studying Ruminant Host-Pathogen Interactions: Smith, D., Price, D. R. G., et al.; Front. Cell. Infect. Microbiol. 11, 733811 (2021), Abstract
Luteolin Attenuates IL-1 β-Induced THP-1 Adhesion to ARPE-19 Cells via Suppression of NF- κ B and MAPK Pathways: W. Huang, et al.; Mediators Inflamm. 2020, 9421340 (2020), Abstract — Full Text
Inhibition of MNK pathways enhances cancer cell response to chemotherapy with temozolomide and targeted radionuclide therapy: M. Grzmil, et al.; Cell. Signal. 28, 1412 (2016), Application(s): Cell culture, Abstract
Roles for TGF-beta and programmed cell death 1 ligand 1 in regulatory T cell expansion and diabetes suppression by zymosan in nonobese diabetic mice: Burton, O. T., Zaccone, P., et al.; J. Immunol. 185, 2754 (2010), Abstract

Related Products

SB-202190

BML-EI294

p38 inhibitor

26 citations

Alternative Name	FHPI, 4-(4-Fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)-1H-imidazole
CAS	152121-30-7
Couple Type	Inhibitor
Purity	≥98% (TLC)

Last modified: May 29, 2024

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SB202190 . hydrochloride

ALX-270-268

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

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