SB-415286

BML-EI311

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GSK inhibitor

Potent and selective inhibitor of GSK-3β (IC₅₀=78nM). Stimulates glycogen synthesis in human liver cells and mimics other actions of insulin. Protects primary neurons from death induced by PI-3 kinase pathway inhibition suggesting therapeutic potential in neurodegenerative diseases and stroke.

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Product Details

Appearance	Yellow Solid.
CAS	264218-23-7
Couple Target	GSK
Couple Type	Inhibitor
Formula	C₁₆H₁₀N₃O₅Cl
Identity	Determined by NMR.
MW	359.7
Purity	≥98% (HPLC)
Solubility	Soluble in DMSO, ethanol or methanol.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

IRAK4 turns IL-10+ phospho-FOXO+ monocytes into pro-inflammatory cells by suppression of protein kinase B: Over, B., Ziegler, S., et al.; Eur. J. Immunol. 43, 1630 (2013), Abstract
Glycogen synthase kinase (GSK)-3 promotes p70 ribosomal protein S6 kinase (p70S6K) activity and cell proliferation: S. Shin, et al.; PNAS 108, E1204 (2011), Application(s): Treatment of HEK293T cells in culture, Abstract — Full Text
Selective small-molecule inhibitors of glycogen synthase kinase-3 activity protect primary neurones from death: D.A.E. Cross, et al.; J. Neurochem. 77, 94 (2001), Abstract
GSK-3 inhibition by adenoviral FRAT1 overexpression is neuroprotective and induces Tau dephosphorylation and beta-catenin stabilisation without elevation of glycogen synthase activity: A.A. Culbert, et al.; FEBS Lett. 507, 288 (2001), Abstract
Selective small molecule inhibitors of glycogen synthase kinase-3 modulate glycogen metabolism and gene transcription: M.P. Coghlan, et al.; Chem. Biol. 7, 793 (2000), Abstract

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SB-415286

BML-EI311

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

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