SB-366791

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TRPV1 antagonist

A potent and selective vanilloid receptor (TRPV1) antagonist. An effective antagonist of hTRPV1 when stimulated by capsaicin, acid, or noxious heat.

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Appearance	Beige solid.
CAS	472981-92-3
Couple Target	TRP channel
Couple Type	Blocker
Formula	C₁₆H₁₄NO₂Cl
MW	287.8
MeltingPoint	165-167°C
Purity	≥98% (TLC)
Solubility	Soluble in DMSO (25mg/ml) or 100% ethanol (10mg/ml with warming).

Use/Stability	As indicated on product label or CoA when stored as recommended. Store, as supplied, at room temperature for up to 1 year. Store solutions at -20°C for up to 3 months.
Long Term Storage	Ambient
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

TRPV1, ASICs and P2X2/3 expressed in bone cells simultaneously regulate bone metabolic markers in ovariectomized mice: K. Kanaya, et al.; J. Musculolskelet. Neuronal Interact. 16, 145 (2016), Abstract
Extracellular pH regulates excitability of vomeronasal sensory neurons: Cichy, A., Ackels, T., et al.; J. Neurosci. 35, 4025 (2015), Abstract
Forced swim-induced musculoskeletal hyperalgesia is mediated by CRF2 receptors but not by TRPV1 receptors: Abdelhamid, R. E., Kovács, K. J., et al.; Neuropharmacology 72, 29 (2013), Abstract
Effects of the novel TRPV1 receptor antagonist SB366791 in vitro and in vivo in the rat: A. Varga, et al.; Neurosci. Lett. 385, 137 (2005), Abstract
Identification and characterisation of SB-366791, a potent and selective vanilloid receptor (VR1/TRPV1) antagonist: M.J. Gunthorpe, et al.; Neuropharmacology 46, 133 (2004), Abstract
Identification of SB-366791, a potent and selective antagonist of vanilloid receptor-1: H.K. Rami, et al.; Drugs Fut. 27 (Supply A), 411 (2002)

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