SB 225002

ALX-270-478

Datasheet
Manual
SDS
CofA

Already have an account?

Chemokine receptor ligand

Potent and selective antagonist of CXCR2 chemokine receptor (IC₅₀=22nM). >150-fold more selective over CXCR1 receptor. Inhibits IL-8- (IC₅₀=8nM) and GROα-mediated (IC₅₀=10nM) calcium mobilisation. Prevents IL-8-induced neutrophil migration. Inhibits HIV replication in lymphocytes and macrophages.

Shipping: Available products typically ship within 24/48h, via priority shipping.

Do you need support? Contact Customer Service or Technical Support.

Online Account
Access or Create Your Account

Product Details

Alternative Name	N-(2-Bromophenyl)-N’-(2-hydroxy-4-nitrophenyl)urea
Appearance	Yellow solid.
CAS	182498-32-4
Couple Target	Chemokine receptor
Couple Type	Ligand
Formula	C₁₃H₁₀BrN₃O₄
Identity	Identity determined by MS, 1H-NMR and 13C-NMR.
MW	352.1
Purity	≥98% (HPLC)
Solubility	Soluble in DMSO (40mg/ml), 100% ethanol or methanol (15mg/ml); slightly soluble in acetonitrile (2mg/ml).

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

CXCR2 antagonists block the N-Ac-PGP-induced neutrophil influx in the airways of mice, but not the production of the chemokine CXCL1: S. Braber, et al.; Eur. J. Pharmacol. 668, 443 (2011), Abstract
A growth-related oncogene/CXC chemokine receptor 2 autocrine loop contributes to cellular proliferation in esophageal cancer: B. Wang, et al.; Cancer Res. 66, 3071 (2006), Abstract — Full Text
Characterization of the molecular interactions of interleukin-8 (CXCL8), growth related oncogen alpha (CXCL1) and a non-peptide antagonist (SB 225002) with the human CXCR2: J. Catusse, et al.; Biochem. Pharmacol. 65, 813 (2003), Abstract
Identification of a potent, selective non-peptide CXCR2 antagonist that inhibits interleukin-8-induced neutrophil migration: J.R. White, et al.; J. Biol. Chem. 273, 10095 (1998), Abstract — Full Text

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

Datasheet

Certificate of Analysis

Please enter the lot number as featured on the product label

Lot No. :

SDS

Enzo Life Science provides GHS Compliant SDS

English (EU) SDS

If your language is not available please fill out the SDS request form

Your Cart

Your Cart

SB 225002

ALX-270-478

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

Certificate of Analysis

SDS

Change Country

Tell us about You

Tell us about your paper

Tell us about You

Tell us about your project