SB 225002

ALX-270-478

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Chemokine receptor ligand

Potent and selective antagonist of CXCR2 chemokine receptor (IC₅₀=22nM). >150-fold more selective over CXCR1 receptor. Inhibits IL-8- (IC₅₀=8nM) and GROα-mediated (IC₅₀=10nM) calcium mobilisation. Prevents IL-8-induced neutrophil migration. Inhibits HIV replication in lymphocytes and macrophages.

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Product Details

Alternative Name	N-(2-Bromophenyl)-N’-(2-hydroxy-4-nitrophenyl)urea
Appearance	Yellow solid.
CAS	182498-32-4
Couple Target	Chemokine receptor
Couple Type	Ligand
Formula	C₁₃H₁₀BrN₃O₄
Identity	Identity determined by MS, 1H-NMR and 13C-NMR.
MW	352.1
Purity	≥98% (HPLC)
Solubility	Soluble in DMSO (40mg/ml), 100% ethanol or methanol (15mg/ml); slightly soluble in acetonitrile (2mg/ml).

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

CXCR2 antagonists block the N-Ac-PGP-induced neutrophil influx in the airways of mice, but not the production of the chemokine CXCL1: S. Braber, et al.; Eur. J. Pharmacol. 668, 443 (2011), Abstract
A growth-related oncogene/CXC chemokine receptor 2 autocrine loop contributes to cellular proliferation in esophageal cancer: B. Wang, et al.; Cancer Res. 66, 3071 (2006), Abstract — Full Text
Characterization of the molecular interactions of interleukin-8 (CXCL8), growth related oncogen alpha (CXCL1) and a non-peptide antagonist (SB 225002) with the human CXCR2: J. Catusse, et al.; Biochem. Pharmacol. 65, 813 (2003), Abstract
Identification of a potent, selective non-peptide CXCR2 antagonist that inhibits interleukin-8-induced neutrophil migration: J.R. White, et al.; J. Biol. Chem. 273, 10095 (1998), Abstract — Full Text

Last modified: May 29, 2024

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SB 225002

ALX-270-478

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