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p38 inhibitor
Cell permeable, potent and selective p38 MAP kinase inhibitor (IC50=30 nM). Inhibits p38α and ß, but not γ and δ isoforms. Does not inhibit ERK2 or other members of the MAP kinase family or their upstream activators. A useful tool for dissecting the role of p38 in signaling pathways. Induces apoptosis.
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Product Details
| Alternative Name |
FHPI, 4-(4-Fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)-1H-imidazole |
|---|---|
| Appearance |
Pale yellow solid. |
| CAS |
152121-30-7 |
| Couple Target |
p38 |
| Couple Type |
Inhibitor |
| Formula |
C20H14FN3O |
| MW |
331.3 |
| Purity |
≥98% (TLC) |
| Solubility |
Soluble in methanol, DMSO or acetone; slightly soluble in ethyl acetate. |
Handling & Storage
| Use/Stability |
As indicated on product label or CoA when stored as recommended. Stable for at least 1 year after receipt when stored, as supplied, at -20°C. Stock solutions are stable for up to 3 months at -20°C. |
|---|---|
| Handling |
Protect from light. |
| Long Term Storage |
-20°C |
| Shipping |
Ambient Temperature |
| Regulatory Status |
RUO – Research Use Only |
|---|
- Bovine Enteroids as an In Vitro Model for Infection with Bovine Coronavirus: R. Shakya, et al.; Viruses 15, 635 (2023), Abstract
- AMP activated kinase negatively regulates hepatic Fetuin-A via p38 MAPK-C/EBPβ/E3 Ubiquitin Ligase Signaling pathway: Kothari, V., Babu, J. R., et al.; PLoS One 17, e0266472 (2022), Abstract
- Inside-out chicken enteroids with leukocyte component as a model to study host-pathogen interactions: T.J. Nash, et al.; Commun. Biol. 4, 377 (2021), Abstract
- Shiga toxin sub-type 2a increases the efficiency of Escherichia coli O157 transmission between animals and restricts epithelial regeneration in bovine enteroids: S.F. Fitzgerald, et al.; PLoS Pathog. 15, e1008003 (2019), Abstract — Full Text
- Development of in vitro enteroids derived from bovine small intestinal crypts: C.A. Hamilton, et al.; Vet. Res. 49, 54 (2018), Abstract — Full Text
- Eupafolin nanoparticles protect HaCaT keratinocytes from particulate matter-induced inflammation and oxidative stress: Z.C. Lin, et al.; Int. J. Nanomedicine 11, 3907 (2016), Application(s): Cell treatment to see effect on PM-induced phosphorylation, Abstract — Full Text
- SOCS1 suppresses IL-1β-induced C/EBPβ expression via transcriptional regulation in human chondrocytes: Y.J. Ha, et al.; Exp. Mol. Med. 48, e241 (2016), Application(s): Transcriptional regulation and CREB phosphorylation activity, Abstract — Full Text
- Extract from Acanthopanax senticosus prevents LPS-induced monocytic cell adhesion via suppression of LFA-1 and Mac-1: H.J. Kim, et al.; Can. J. Physiol. Pharmacol. 92, 278 (2014), Application(s): PCR experiments revealed that AS extract inhibited LPS-induced expression of genes encoding lymphocyte function-associated antigen-1 (LFA-1) and macrophage-1 antigen (Mac-1) in THP-1 cells, Abstract
- PTX3 Stimulates Osteoclastogenesis by Increasing Osteoblast RANKL Production: E.J. Lee, et al.; J. Cell. Physiol. 229, 1744 (2014), Application(s): Knock-down of endogenous PTX3 with small-interfering RNA did not change the osteogenic potential of pOBs but suppressed their production of RANKL and reduced osteoclastogenesis, Abstract
- The prostaglandin E2 receptor EP4 is integral to a positive feedback loop for prostaglandin E2 production in human macrophages infected with Mycobacterium tuberculosis: T. Nishimura, et al.; FASEB J. 27, 3827 (2013), Application(s): PGE2 production induced by pathogen recognition receptors/p38 MAPK signaling is up-regulated by EP4-triggered signaling to maintain an effective PGE2 concentration, Abstract
- Systems kinomics demonstrates Congo Basin monkeypox virus infection selectively modulates host cell signaling responses as compared to West African monkeypox virus: J. Kindrachuk, et al.; Mol. Cell. Proteomics 11, M111.015701 (2012), Application(s): ELISA, Abstract — Full Text
- Nitric oxide induces cell death in canine cruciate ligament cells by activation of tyrosine kinase and reactive oxygen species: S. Forterre, et al.; BMC Vet. Res. 8, 40 (2012), Application(s): WB, Assays, Abstract — Full Text
- Human NDR kinases control G(1)/S cell cycle transition by directly regulating p21 stability: H. Cornils, et al.; Mol. Cell. Biol. 31, 1382 (2011), Application(s): IP, WB, Assays, Abstract — Full Text
- Epithelial cell senescence impairs repair process and exacerbates inflammation after airway injury: F. Zhou, et al.; Respir. Res. 12, 78 (2011), Application(s): ELISA, WB, IHC, IF, Abstract — Full Text
- Roles for TGF-beta and programmed cell death 1 ligand 1 in regulatory T cell expansion and diabetes suppression by zymosan in nonobese diabetic mice: O.T. Burton, et al.; J. Immunol. 185, 2754 (2010), Application(s): Flow, PCR, Abstract — Full Text
- Manganese chloride stimulates rat microglia to release hydrogen peroxide: Zhang, P., Hatter, A., et al.; Toxicol. Lett. 173, 88 (2007), Abstract
- 4-Hydroxytamoxifen inhibits proliferation of multiple myeloma cells in vitro through down-regulation of c-Myc, up-regulation of p27Kip1, and modulation of Bcl-2 family members: Gauduchon, J., Gouilleux, F., et al.; Clin. Cancer Res. 11, 2345 (2005), Abstract
- One-way cross-talk between p38(MAPK) and p42/44(MAPK). Inhibition of p38(MAPK) induces low density lipoprotein receptor expression through activation of the p42/44(MAPK) cascade: R.P. Singh, et al.; J. Biol. Chem. 274, 19593 (1999), Abstract
- The cellular response to oxidative stress: influences of mitogen-activated protein kinase signalling pathways on cell survival: X. Wang, et al.; Biochem. J. 333, 291 (1998), Abstract
- A single amino acid substitution makes ERK2 susceptible to pyridinyl imidazole inhibitors of p38 MAP kinase: T. Fox, et al.; Protein Sci. 7, 2249 (1998), Abstract
- Induction of apoptosis by SB202190 through inhibition of p38beta mitogen-activated protein kinase: S. Nemoto, et al.; J. Biol. Chem. 273, 16415 (1998), Abstract
- Regulation of stress-induced cytokine production by pyridinylimidazoles; inhibition of CSBP kinase: T.F. Gallagher, et al.; Bioorg. Med. Chem. 5, 49 (1997), Abstract
- The primary structure of p38 gamma: a new member of p38 group of MAP kinases: Z. Li, et al.; Biochem. Biophys. Res. Commun. 228, 334 (1996), Abstract
- Characterization of the structure and function of a new mitogen-activated protein kinase (p38beta): Y. Jiang, et al.; J. Biol. Chem. 271, 17920 (1996), Abstract
- SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1: A. Cuenda, et al.; FEBS Lett. 364, 229 (1995), Abstract
- A protein kinase involved in the regulation of inflammatory cytokine biosynthesis: J.C. Lee, et al.; Nature 372, 739 (1994), Abstract
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