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SARM (SAM and ARM-containing protein) is thought to serve as an adaptor protein for the Toll-like receptors (TLRs) and allow for the activation of downstream kinases and NF-κB, ultimately leading to the expression of proteins involved in host defense. While SARM has not been conclusively shown to associate directly with TLRs, the presence of a Toll-interleukin-1 (TIR) domain in SARM is consistent with a role as a signaling molecule.
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Western blot analysis of SARM in Daudi cell lysates with SARM antibody at (A) 0.5, (B) 1, and (C) 2µg/ml.
Immunocytochemistry analysis of Daudi cells using SARM antibody at 2µg/ml.
| Regulatory Status |
RUO – Research Use Only |
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