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Saposin C (human), (recombinant)

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An essential activator for glucocerebrosidase, the enzyme deficient in Gaucher disease.

Glycoprotein with a variety of functions. Important for exchange of lipids from CD1 molecules to lysosomal antigens.

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Alternative Name	Co-β-glucosidase, A1 activator, Glucosylceramidase activator, Sphingolipid activator protein 2, SAP-2
Endotoxin Content	<0.1EU/µg purified protein (LAL test; Bio Whittaker).
Formulation	Lyophilized. In 50mM Tris, pH 6.0, containing 150mM sodium chloride.
MW	~8kDa
Purity	≥95% (SDS-PAGE)
Reconstitution	Reconstitute with 100µl sterile water.
Source	Produced in E. coli. Human recombinant saposin C (aa 309-388) is fused at the C-terminus to a His-tag and at the N-terminus to a T-7-tag.
UniProt ID	P07602

Use/Stability	Stable for at least one year after receipt when stored at +4°C.
Long Term Storage	+4°C
Shipping	Blue Ice

Regulatory Status	RUO – Research Use Only

Lysosomal processing of sulfatide analogs alters target NKT cell specificity and immune responses in cancer: K. Nishio, et al.; J. Clin. Invest. 134, e165281 (2023), Abstract
Lysosomal ceramides regulate cathepsin B-mediated processing of saposin C and glucocerebrosidase activity: Kim, M. J., Jeong, H., et al.; Hum. Mol. Genet. 31, 2424 (2022), Abstract
Editing of CD1d-bound lipid antigens by endosomal lipid transfer proteins: D. Zhou, et al.; Science 303, 523 (2004), Abstract
Saposin C is required for lipid presentation by human CD1b: F. Winau, et al.; Nat. Immunol. 5, 169 (2004), Abstract

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