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Sanguinarine chloride

ALX-350-076

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Na⁺/K⁺– and Mg²⁺-ATPase inhibitor

Na⁺/K⁺-and Mg²⁺-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. Modulates the Bcl-2 family. Shows antiplaque activity in humans.

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Product Details

Alternative Name	Pseudochelerythrine
Appearance	Orange solid.
CAS	5578-73-4
Couple Target	ATPase
Couple Type	Inhibitor
Formula	C₂₀H₁₄NO₄Cl
MI	14: 8356
MW	367.8
Purity	≥98% (HPLC)
RTECS	VP5220000
Solubility	Soluble in methanol; slightly soluble in water.
Source	Isolated from the leaves and stems of Macleaya cordata and M. microcarpa.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	+4°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Induction of apoptosis by sanguinarine in C6 rat glioblastoma cells is associated with the modulation of the Bcl-2 family and activation of caspases through downregulation of extracellular signal-regulated kinase and Akt: M.H. Han, et al.; Anticancer Drugs 18, 913 (2007), Abstract
Metabolism of sanguinarine: the facts and the myths: Z. Dvorak & V. Simanek; Curr. Drug Metab. 8, 173 (2007), Review, Abstract
The effect of chelerythrine on cell growth, apoptosis, and cell cycle in human normal and cancer cells in comparison with sanguinarine: J. Malikova, et al.; Cell Biol. Toxicol. 22, 439 (2006), Abstract
Chelerythrine and sanguinarine dock at distinct sites on BclXL that are not the classic BH3 binding cleft: Y.H. Zhang, et al.; J. Mol. Biol. 364, 538 (2006), Abstract
Sanguinarine-induced apoptosis is associated with an early and severe cellular glutathione depletion: E. Debiton, et al.; Cancer Chemother. Pharmacol. 51, 474 (2003), Abstract
Activation of prodeath Bcl-2 family proteins and mitochondrial apoptosis pathway by sanguinarine in immortalized human HaCaT keratinocytes: V.M. Adhami, et al.; Clin. Cancer Res. 9, 3176 (2003), Abstract
Sanguinarine, a new antiplaque agent: retention and plaque specificity: G.L. Southard, et al.; J. Am. Dent. Assoc. 108, 338 (1984), Abstract
Isoquinoline alkaloids. Inhibitory actions on cation-dependent ATP-phosphohydrolases: L.R. Meyerson, et al.; Neurochem. Res. 3, 239 (1978), Abstract
Sanguinarine, inhibitor of Na-K dependent ATP’ase: K.D. Straub & P. Carver; BBRC 62, 913 (1975), Abstract

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Sanguinarine chloride

ALX-350-076

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

Certificate of Analysis

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