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Salubrinal

ALX-270-428

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Cell permeable and selective inhibitor of the phosphatase complexes that dephosphorylate eukaryotic translation initiation factor 2 subunit α (eIF-2α). Protects ER stress-induced apoptosis (EC₅₀~15µM in PC12 cells stimulated with 750ng/ml of tunicamycin (Prod. No. BML-CC104)).

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Product Details

Appearance	White to off-white powder.
CAS	405060-95-9
Formula	C₂₁H₁₇Cl₃N₄OS
Identity	Determined by MS, 1H-NMR and 13C-NMR.
MW	479.8
Purity	≥98% (HPLC(UV))
Solubility	Soluble in DMSO (300 mg/ml), dioxane (0.5 mg/ml), methanol (5 mg/ml) or acetonitrile (1.5 mg/ml).

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Product may darken when exposed to air. Stock solutions are stable for up to 3 months when stored at -20°C.
Handling	Protect from light. Keep under inert gas.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Gallotannin attenuates 2‑deoxy‑D‑glucose‑induced dedifferentiation and endoplasmic reticulum stress through inhibition of inositol‑requiring enzyme 1 downstream p38 kinase pathway in chondrocytes: Kim, S. M., Han, Y., et al.; Mol. Med. Rep. 20, 5249 (2019), Abstract
3,3’-Diindolylmethane (DIM) and its ring-substituted halogenated analogs (ring-DIMs) induce differential mechanisms of survival and death in androgen-dependent and -independent prostate cancer cells: A.A. Goldberg, et al.; Genes Cancer 6, 265 (2015), Application(s): Cell Culture, Abstract — Full Text
BRAF- and MEK-Targeted Small Molecule Inhibitors Exert Enhanced Antimelanoma Effects in Combination With Oncolytic Reovirus Through ER Stress: Roulstone, V., Pedersen, M., et al.; Mol. Ther. 23, 931 (2015), Abstract
CD36 deletion improves recovery from spinal cord injury: Myers, S. A., Andres, K. R., et al.; Exp. Neurol. 256, 25 (2014), Abstract
Inhibition of eIF2α dephosphorylation enhances TRAIL-induced apoptosis in hepatoma cells: Teng, Y., Gao, M., et al.; Cell Death Dis. 5, e1060 (2014), Application(s): In Vitro, Abstract
Neuroprotection through excitability and mTOR required in ALS motoneurons to delay disease and extend survival: Saxena, S., Roselli, F., et al.; Neuron 80, 80 (2013), Abstract
Endoplasmic reticulum stress is important for the manifestations of α-synucleinopathy in vivo: Colla, E., Coune, P., et al.; J. Neurosci. 32, 3306 (2012), Abstract
Early endosomes and endosomal coatomer are required for autophagy: M. Razi, et al.; J. Cell Biol. 185, 305 (2009), Abstract
A pharmacoproteomic approach implicates eukaryotic elongation factor 2 kinase in ER stress-induced cell death: M. Boyce, et al.; Cell Death Differ. 15, 589 (2008), Abstract
A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress: M. Boyce, et al.; Science 307, 935 (2005), Abstract

Related Products

Tunicamycin

BML-CC104

GlcNAc phosphotransferase inhibitor

28 citations

CAS	11089-65-9
Couple Type	Inhibitor
Purity	≥99% (TLC)

Last modified: May 29, 2024

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Salubrinal

ALX-270-428

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