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S-Trityl-L-cysteine

ALX-105-011

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Cell cycle blocker

Potent, cell permeable cysteine thioether displaying anti-mitotic and anti-tumor properties. Inhibits mitosis by blocking basal and microtubule-activated ATPase activities of the mitotic kinesin Eg5 (IC₅₀=1µM and 140nm). Induces mitotic arrest in HeLa cells (IC₅₀=700nM) and inhibits the growth of NCI tumor cell line panel (GI₅₀=1.31µM).

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Product Details

Alternative Name	NSC 83265, STLC
Appearance	White to off-white solid.
CAS	2799-07-7
Couple Target	Kinesin
Couple Type	Inhibitor
Formula	C₂₂H₂₁NO₂S
MW	363.5
Purity	≥98% (TLC)
RTECS	AY7710000
Solubility	Soluble in DMSO or acetic acid.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Cohesin-mediated DNA loop extrusion resolves sister chromatids in G2 phase: Batty, P., Langer, C. C. H., et al.; EMBO J. 42, e113475 (2023), Abstract
Mitotic tethering enables inheritance of shattered micronuclear chromosomes: Trivedi, P., Steele, C. D., et al.; Nature 618, 1049 (2023), Abstract
A mitotic chromatin phase transition prevents perforation by microtubules: M.W.G. Schneider, et al.; Nature 609, 183 (2022), Abstract
Fragile X-Related Protein 1 Regulates Nucleoporin Localization in a Cell Cycle-Dependent Manner: Agote-Arán, A., Lin, J., et al.; Front Cell Dev Biol 9, 755847 (2022), Abstract
Mitotic tethering enables en masse inheritance of a shattered micronuclear chromosome: Trivedi, P., Steele, C. D., et al.; bioRxiv , (2022)
A PKD-MFF signaling axis couples mitochondrial fission to mitotic progression: E. Pangou, et al.; Cell Rep. 35, 109129 (2021), Abstract
A chromatin phase transition protects mitotic chromosomes against microtubule perforation: Schneider, M. W. G., Gibson, B. A., et al.; bioRxiv , (2021)
Deubiquitylase UCHL3 drives error correction at kinetochores and chromosome segregation independent of spindle assembly checkpoint: Jerabkova, K., Liao, Y., et al.; bioRxiv , (2020)
Deubiquitylase UCHL3 regulates bi-orientation and segregation of chromosomes during mitosis: Jerabkova, K., Liao, Y., et al.; FASEB J. 34, 12751 (2020), Abstract
Kinesin molecular motor Eg5 functions during polypeptide synthesis: Bartoli, K. M., Jakovljevic, J., et al.; Mol. Biol. Cell 22, 3420 (2011), Abstract

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S-Trityl-L-cysteine

ALX-105-011

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

Certificate of Analysis

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