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(S)-Roscovitine

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CDK1 inhibitor

(S)-Enantiomer of the CDK inhibitor roscovitine (Prod. No. BML-CC205). Potent inhibitor of CDK1/cyclin B kinase (IC₅₀=950nM).

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Alternative Name	6-Benzylamino-2-(S)-[(1-Ethyl)-2-hydroxyethylamino]-9-isopropylpurine
Appearance	White to off-white solid.
CAS	186692-45-5
Couple Target	CDK
Couple Type	Inhibitor
Formula	C₁₉H₂₆N₆O
MW	354.5
Purity	≥98% (HPLC)
Solubility	Soluble in DMSO, dimethyl formamide, 100% ethanol or methanol.

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Roscovitine binds to novel L-channel (CaV1.2) sites that separately affect activation and inactivation: V. Yarotskyy, et al.; J. Biol. Chem. 285, 43 (2010), Abstract
In vitro maturation and fertilization of porcine oocytes after a 48 h culture in roscovitine, an inhibitor of p34cdc2/cyclin B kinase: R. Romar & H. Funahashi; Anim. Reprod. Sci. 92, 321 (2006), Abstract
Maintenance of meiotic arrest in bovine oocytes using the S-enantiomer of roscovitine: effects on maturation, fertilization and subsequent embryo development in vitro: P. Coy, et al.; Reproduction 129, 19 (2005), Abstract
The cyclin-dependent kinase inhibitors olomoucine and roscovitine arrest human fibroblasts in G1 phase by specific inhibition of CDK2 kinase activity: F. Alessi, et al.; Exp. Cell Res. 245, 8 (1998), Abstract
Cytokinin-derived cyclin-dependent kinase inhibitors: synthesis and cdc2 inhibitory activity of olomoucine and related compounds: L. Havlicek, et al.; J. Med. Chem. 40, 408 (1997), Abstract
Inhibition of cyclin-dependent kinases by purine analogues: crystal structure of human cdk2 complexed with roscovitine: W.F. De Azevedo, et al.; Eur. J. Biochem. 243, 518 (1997), Abstract

Related Products

CDK inhibitor

Alternative Name	6-Benzylamino-2-(R)-[(1-ethyl)-2-hydroxyethylamino]-9-isopropylpurine, 2(R)-(1-Ethyl-2-hydroxyethylamino)-6-benzylamino-9-isopropylpurine, Seliciclib
CAS	186692-46-6
Couple Type	Inhibitor
Purity	≥95% (HPLC, TLC)

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