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(S)-ESBA . HCl

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Kynurenine aminotransferase inhibitor

Potent and selective mouse/rat kynurenine aminotransferase II (KAT II) inhibitor. IC₅₀=6.1µM.

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Alternative Name	(S)-(4-Ethylsulfonyl)benzoylalanine . hydrochloride
Appearance	White to off-white powder.
Couple Target	Kynurenine aminotransferase
Couple Type	Inhibitor
Formula	C₁₂H₁₅NO₅S . HCl
MW	285.3 . 36.5
Purity	≥97% (HPLC)
Solubility	Soluble in water or DMSO.

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Specific inhibition of kynurenate synthesis enhances extracellular dopamine levels in the rodent striatum: L. Amori, et al.; Neuroscience 159, 196 (2009), Abstract
Sequence variants in kynurenine aminotransferase II (KAT II) orthologs determine different potencies of the inhibitor S-ESBA: R. Pellicciari, et al.; ChemMedChem 3, 1199 (2008), Abstract
Curiosity to kill the KAT (kynurenine aminotransferase): structural insights into brain kynurenic acid synthesis: F. Rossi, et al.; Curr. Opin. Struct. Biol. 18, 748 (2008), Abstract
Toxoplasma gondii and schizophrenia: linkage through astrocyte-derived kynurenic acid?: R. Schwarcz & C.A. Hunter; Shizophr. Bull. 33, 652 (2007), Abstract — Full Text
Modulators of the kynurenine pathway of tryptophan metabolism: synthesis and preliminary biological evaluation of (S)-4-(ethylsulfonyl)benzoylalanine, a potent and selective kynurenine aminotransferase II (KAT II) inhibitor: R. Pellicciari, et al.; ChemMedChem 1, 528 (2006), Abstract

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