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(S)-(+)-Camptothecin

ALX-350-015

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Potent antitumor agent

Potent antitumor agent. Inhibitor of DNA-topoisomerase I. Activates p53 resulting in upregulated expression of TRAIL-R2 (DR5) and Bak to overcome TRAIL resistance in Bax-deficient human colon carcinoma cells. Inhinbits Tat-mediated transactivation of HIV-1. Induces apoptosis in osteosarcoma and hepatoma cells. Suppresses nitric oxide (NO) biosynthesis.

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Product Details

Appearance	Light yellow powder or needle-shaped crystal.
CAS	7689-03-4
Couple Target	p53, Topoisomerase
Couple Type	Activator, Inhibitor
Formula	C₂₀H₁₆N₂O₄
Identity	Determined by IR.
MI	14: 1735
MW	348.4
Purity	≥98% (HPLC)
RTECS	UQ0492000
Solubility	Soluble in DMSO (10mg/ml), methanol (40mg/ml), 0.1N sodium hydroxide (50mg/ml) or acetic acid; insoluble in water.
Source	Isolated from Camptotheca acuminata seeds.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Handling	Protect from light and moisture. After reconstitution, prepare aliquots and store at -20°C.
Long Term Storage	+4°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

An Atypical, Staged Cell Death Pathway Induced by Depletion of SNARE-Proteins MUNC18-1 or Syntaxin-1: F.M. Feringa, et al.; J. Neurosci. 43, 347 (2023), Abstract
Endoplasmic reticulum stress in mouse decidua during early pregnancy: X.W. Gu, et al.; Mol. Cell. Endocrinol. 434, 48 (2016), Application(s): Cell culture, stromal cells, Abstract
Hypoxia pathway and hypoxia-mediated extensive extramedullary hematopoiesis are involved in ursolic acid’s anti-metastatic effect in 4T1 tumor bearing mice: Gao, J. L., Shui, Y. M., et al.; Oncotarget 7, 71802 (2016), Abstract
Three-Dimensional (3D) Cell Cultures in Cell-based Assays for in-vitro Evaluation of Anticancer Drugs: A.F. Adcock, et al.; J. Anal. Bioanal. Tech. 6, 3 (2015), Application(s): Drug Treatment, Full Text
The p53 binding protein PDCD5 is not rate-limiting in DNA damage induced cell death: F. J. Bock, et al.; Sci. Rep. 5, 11268 (2015), Application(s): Cell Culture, Abstract — Full Text
Sod1 Loss Induces Intrinsic Superoxide Accumulation Leading to p53-Mediated Growth Arrest and Apoptosis: K. Watanabe, et al.; Int. J. Mol. Sci. 14, 10998 (2013), Application(s): Treatment of NIH3T3 cell to induce DNA damage, Abstract — Full Text
Tetrandrine inhibits Wnt/β-catenin signaling and suppresses tumor growth of human colorectal cancer: He, B. C., Gao, J. L., et al.; Mol. Pharmacol. 79, 211 (2011), Abstract
Synergistic antitumor effect between vorinostat and topotecan in small cell lung cancer cells is mediated by generation of reactive oxygen species and DNA damage-induced apoptosis: Bruzzese, F., Rocco, M., et al.; Mol. Cancer Ther. 8, 3075 (2009), Abstract
The antiviral adaptor proteins Cardif and Trif are processed and inactivated by caspases: M. Rebsamen, et al.; Cell Death Differ. 15, 1804 (2008), Abstract
The effects of camptothecin on RNA polymerase II transcription: roles of DNA topoisomerase I:: G. Capranico, et al.; Biochimie 89, 482 (2007), Abstract