Potent antitumor agent
Potent antitumor agent. Inhibitor of DNA-topoisomerase I. Activates p53 resulting in upregulated expression of TRAIL-R2 (DR5) and Bak to overcome TRAIL resistance in Bax-deficient human colon carcinoma cells. Inhinbits Tat-mediated transactivation of HIV-1. Induces apoptosis in osteosarcoma and hepatoma cells. Suppresses nitric oxide (NO) biosynthesis.
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Product Details
Appearance |
Light yellow powder or needle-shaped crystal. |
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CAS |
7689-03-4 |
Couple Target |
p53, Topoisomerase |
Couple Type |
Activator, Inhibitor |
Formula |
C20H16N2O4 |
Identity |
Determined by IR. |
MI |
14: 1735 |
MW |
348.4 |
Purity |
≥98% (HPLC) |
RTECS |
UQ0492000 |
Solubility |
Soluble in DMSO (10mg/ml), methanol (40mg/ml), 0.1N sodium hydroxide (50mg/ml) or acetic acid; insoluble in water. |
Source |
Isolated from Camptotheca acuminata seeds. |
Handling & Storage
Use/Stability |
As indicated on product label or CoA when stored as recommended. |
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Handling |
Protect from light and moisture. After reconstitution, prepare aliquots and store at -20°C. |
Long Term Storage |
+4°C |
Shipping |
Ambient Temperature |
Regulatory Status |
RUO – Research Use Only |
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- An Atypical, Staged Cell Death Pathway Induced by Depletion of SNARE-Proteins MUNC18-1 or Syntaxin-1: F.M. Feringa, et al.; J. Neurosci. 43, 347 (2023), Abstract
- Endoplasmic reticulum stress in mouse decidua during early pregnancy: X.W. Gu, et al.; Mol. Cell. Endocrinol. 434, 48 (2016), Application(s): Cell culture, stromal cells, Abstract
- Hypoxia pathway and hypoxia-mediated extensive extramedullary hematopoiesis are involved in ursolic acid’s anti-metastatic effect in 4T1 tumor bearing mice: Gao, J. L., Shui, Y. M., et al.; Oncotarget 7, 71802 (2016), Abstract
- Three-Dimensional (3D) Cell Cultures in Cell-based Assays for in-vitro Evaluation of Anticancer Drugs: A.F. Adcock, et al.; J. Anal. Bioanal. Tech. 6, 3 (2015), Application(s): Drug Treatment, Full Text
- The p53 binding protein PDCD5 is not rate-limiting in DNA damage induced cell death: F. J. Bock, et al.; Sci. Rep. 5, 11268 (2015), Application(s): Cell Culture, Abstract — Full Text
- Sod1 Loss Induces Intrinsic Superoxide Accumulation Leading to p53-Mediated Growth Arrest and Apoptosis: K. Watanabe, et al.; Int. J. Mol. Sci. 14, 10998 (2013), Application(s): Treatment of NIH3T3 cell to induce DNA damage, Abstract — Full Text
- Tetrandrine inhibits Wnt/β-catenin signaling and suppresses tumor growth of human colorectal cancer: He, B. C., Gao, J. L., et al.; Mol. Pharmacol. 79, 211 (2011), Abstract
- Synergistic antitumor effect between vorinostat and topotecan in small cell lung cancer cells is mediated by generation of reactive oxygen species and DNA damage-induced apoptosis: Bruzzese, F., Rocco, M., et al.; Mol. Cancer Ther. 8, 3075 (2009), Abstract
- The antiviral adaptor proteins Cardif and Trif are processed and inactivated by caspases: M. Rebsamen, et al.; Cell Death Differ. 15, 1804 (2008), Abstract
- The effects of camptothecin on RNA polymerase II transcription: roles of DNA topoisomerase I:: G. Capranico, et al.; Biochimie 89, 482 (2007), Abstract
- Camptothecin and its analogues: a review on their chemotherapeutic potential: D. Sriram, et al.; Nat. Prod. Res. 19, 393 (2005), Review, Abstract
- Camptothecin and taxol: historic achievements in natural products research: N.H. Oberlies & D.J. Kroll; J. Nat. Prod. 67, 129 (2004), Review, Abstract
- Reversal of multidrug resistance-associated protein-mediated daunorubicin resistance by camptothecin: D. Chauvier, et al.; J. Pharm. Sci. 91, 1765 (2002), Abstract
- Camptothecin suppresses nitric oxide biosynthesis in RAW 264.7 macrophages: W.F. Chiou, et al.; Life Sci. 69, 625 (2001), Abstract
- Camptothecin and taxol: discovery to clinic: M.E. Wall; Med. Res. Rev. 18, 299 (1998), Review, Abstract
- Camptothecin-induced apoptosis in p53-null human leukemia HL60 cells and their isolated nuclei: effects of the protease inhibitors Z-VAD-fmk and dichloroisocoumarin suggest an involvement of both caspases and serine proteases: T. Shimizu & Y. Pommier; Leukemia 11, 1238 (1997), Abstract
- Chemotherapeutic agent CPT-11 induces the new expression of the apoptosis initiator to the cytoplasm: A. Suzuki & M. Kato; Exp. Cell. Res. 227, 154 (1996), Abstract
- The anti-cancer drug camptothecin inhibits elongation but stimulates initiation of RNA polymerase II transcription: M. Ljungman & P.C. Hanawalt; Carcinogenesis 17, 31 (1996), Abstract
- The cell cycle effects of camptothecin: Z. Darzynkiewicz, et al.; Ann. N. Y. Acad. Sci. 803, 93 (1996), Abstract
- Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis: D.W. Nicholson, et al.; Nature 376, 37 (1995), Abstract
- Forskolin and camptothecin induce a 30 kDa protein associated with melatonin production in Y79 human retinoblastoma cells: J.L. Janavs, et al.; J. Neurosci. 15, 298 (1995), Abstract
- Differential stabilization of eukaryotic DNA topoisomerase I cleavable complexes by camptothecin derivatives: A. Tanizawa, et al.; Biochemistry 34, 7200 (1995), Abstract
- Camptothecins: from bench research to hospital wards: M. Potmesil; Cancer Res. 54, 1431 (1994), (Review), Abstract
- RNA synthesis inhibitors increase melatonin production in Y79 human retinoblastoma cells: J.L. Janavs, et al.; Mol. Brain Res. 23, 47 (1994), Abstract
- Camptothecin inhibits Tat-mediated transactivation of type 1 human immunodeficiency virus: C.J. Li, et al.; J. Biol. Chem. 269, 7051 (1994), Abstract
- The current status of camptothecin analogues as antitumor agents: W.J. Slichenmyer, et al.; J. Natl. Cancer Inst. 85, 271 (1993), (Review), Abstract
- Irreversible trapping of the DNA-topoisomerase I covalent complex. Affinity labeling of the camptothecin binding site: R.P. Hertzberg, et al.; J. Biol. Chem. 265, 19287 (1990), Abstract
- On the mechanism of topoisomerase I inhibition by camptothecin: evidence for binding to an enzyme-DNA complex: R.P. Hertzberg, et al.; Biochemistry 28, 4629 (1989), Abstract
- Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I: Y.H. Hsiang, et al.; J. Biol. Chem. 260, 14873 (1985), Abstract
- Plant Antitumor Agents. I. The Isolation and Structure of Camptothecin, a Novel Alkaloidal Leukemia and Tumor Inhibitor from Camptotheca acuminata: M.E. Wall, et al.; JACS 88, 3888 (1966), Abstract
Related Products

Alternative Name | 9-[(Dimethylamino)methyl]-10-hydroxy-(20S)-camptothecin . HCl |
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CAS | 119413-54-6 |
Couple Type | Inhibitor |
Purity | ≥98% (HPLC) |
Last modified: May 29, 2024
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