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Ca2+ channel activator
Induces the release of intracellular Ca2+ . Ryanodine receptors mediate adenine nucleotide, Ca2+ and caffeine-sensitive release of Ca2+ from sarcoplasmic reticulum of cardiac and skeletal muscle and may also mediate intracellular Ca2+ release in neurons. Biphasic effect on sarcoplasmic reticulum calcium channels; Nanomolar levels open the channel and micromolar levels close it.
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Product Details
| Appearance |
White to off-white solid. |
|---|---|
| CAS |
15662-33-6 |
| Couple Target |
Calcium channel |
| Couple Type |
Activator |
| Formula |
C25H35NO9 |
| MI |
14: 8307 |
| MW |
493.5 |
| Purity |
≥99% (HPLC) |
| RTECS |
VM4025000 |
| Solubility |
Soluble in methanol or DMSO (>29mg/ml), in 100% ethanol (16mg/ml); slightly soluble in water (warm). |
| Source |
Isolated from Ryania speciosa, Flacourtiaceae. |
Handling & Storage
| Use/Stability |
As indicated on product label or CoA when stored as recommended. |
|---|---|
| Handling |
Protect from light. |
| Long Term Storage |
-20°C |
| Shipping |
Ambient Temperature |
| Regulatory Status |
RUO – Research Use Only |
|---|
- Inactive ryanodine receptors sustain lysosomal availability for autophagy by promoting ER-lysosomal contact site formation: Vervliet, T., Loncke, J., et al.; Research Square , (2024)
- Imeglimin amplifies glucose-stimulated insulin release from diabetic islets via a distinct mechanism of action: Hallakou-Bozec, S., Kergoat, M., et al.; PLoS One 16, e0241651 (2021), Abstract
- MyoScreen, a High-Throughput Phenotypic Screening Platform Enabling Muscle Drug Discovery: Young, J., Margaron, Y., et al.; SLAS Discov. 23, 790 (2018), Abstract
- All three IP3 receptor isoforms generate Ca2+ puffs that display similar characteristics: Lock, J. T., Alzayady, K. J., et al.; Sci. Signal. 11, (2018), Abstract
- Increased calcium leak associated with reduced calsequestrin expression in hyperthyroid cardiomyocytes: D.R. de Alba-Aguayo, et al.; Cell Calcium 62, 29 (2017), Abstract
- Voltage Dependence of a Neuromodulator-Activated Ionic Current: Gray, M., Golowasch, J., et al.; eNeuro 3, (2016), Abstract
- Opposing roles of smooth muscle BK channels and ryanodine receptors in the regulation of nerve-evoked constriction of mesenteric resistance arteries: Krishnamoorthy, G., Sonkusare, S. K., et al.; Am. J. Physiol. Heart Circ. Physiol. 306, H981 (2014), Abstract
- Large-conductance voltage- and Ca2+-activated K+ channel regulation by protein kinase C in guinea pig urinary bladder smooth muscle: Hristov, K. L., Smith, A. C., et al.; Am. J. Physiol. Cell Physiol. 306, C460 (2014), Abstract
- Activation of muscarinic M3 receptors inhibits large-conductance voltage- and Ca2+-activated K+ channels in rat urinary bladder smooth muscle cells: Parajuli, S. P., Petkov, G. V., et al.; Am. J. Physiol. Cell Physiol. 305, C207 (2013), Abstract
- Selective inhibition of phosphodiesterase 1 relaxes urinary bladder smooth muscle: role for ryanodine receptor-mediated BK channel activation: W. Xin, et al.; Am. J. Physiol. Cell Physiol. 303, C1079 (2012), Application(s): ELISA analysis of guinea pig and human DSM cells, Abstract — Full Text
- Involvement of ryanodine receptors in neurotrophin-induced hippocampal synaptic plasticity and spatial memory formation: T. Adasme, et al.; PNAS U.S.A. 108, 3029 (2011), Abstract — Full Text
- I(f) and SR Ca(2+) release both contribute to pacemaker activity in canine sinoatrial node cells: Gao, Z., Chen, B., et al.; J. Mol. Cell. Cardiol. 49, 33 (2010), Abstract
- The interaction of ryanoids with individual ryanodine receptor channels: A. J. Williams and B. Tanna; Biol. Res. 37, 527 (2004), Abstract
- The pharmacology of ryanodine and related compounds: J. L. Sutko, et al.; Pharmacol. Rev. 49, 53 (1997), Abstract
- The ryanodine receptor/Ca2+ release channel: P.S. McPherson & K.P. Campbell; J. Biol. Chem. 268, 13765 (1993), Abstract
- Cyclic ADP-ribose: a new way to control calcium: A. Galione; Science 259, 325 (1993), Abstract
- Ryanodine as a functional probe of the skeletal muscle sarcoplasmic reticulum Ca2+ release channel: G. Meissner & A. el-Hashem; Mol. Cell. Biochem. 114, 119 (1992), Abstract
- The brain ryanodine receptor: a caffeine-sensitive calcium release channel: P.S. McPherson et al.; Neuron 7, 17 (1991), Abstract
- Depolarization promotes caffeine induced [3H]-noradrenaline release in calcium-free solution from peripheral sympathetic nerves: P.T. Toth et al.; Cell. Calcium 11, 557 (1990), Abstract
- Rapid kinetic analysis of the calcium-release channels of skeletal muscle sarcoplasmic reticulum: the effect of inhibitors: G. Calviello & M. Chiesi; Biochemistry 28, 1301 (1989), Abstract
- Structural aspects of ryanodine action and selectivity: A.L. Waterhouse, et al.; J. Med. Chem. 30, 710 (1987), Abstract
- Rapid flow chemical quench studies of calcium release from isolated sarcoplasmic reticulum: N. Ikemoto et al.; J. Biol. Chem. 260, 14096 (1985), Abstract
- The calcium-ryanodine receptor complex of skeletal and cardiac muscle: I.N. Pessah, et al.; BBRC 128, 449 (1985), Abstract
- Mechanism of action of ryanodine on cardiac sarcoplasmic reticulum: J.J. Feher & G.B. Lipford; Biochim. Biophys. Acta 813, 77 (1985), Abstract
- Ryanodine: a modifier of sarcoplasmic reticulum calcium release in striated muscle: J.L. Sutko, et al.; Fed. Prod. 44, 2984 (1985), Abstract
- Ryanodine modification of cardiac muscle responses to potassium-free solutions. Evidence for inhibition of sarcoplasmic reticulum calcium release: J.L. Sutko & J.L. Kenyon; J. Gen. Physiol. 82, 385 (1983), Abstract
- The pharmacology of ryanodine: D.J. Jenden & A.S. Fairhurst; Pharmacol. Rev. 21, 1 (1969), (Review), Abstract
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