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RWJ-60475-(AM)3 is a cell-permeable acetoxymethyl (AM) ester of RWJ-60475. The AM esters confer cell membrane permeability and are hydrolyzed by intracellular esterases, trapping the active inhibitor within the cell. The IC50 for the hydrolyzed, active inhibitor is 2 µM.
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Last modified: May 29, 2024