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Capsaicin and Ca2+ antagonist
Blocks TRPV1. Capsaicin and calcium antagonist. Inhibitor of Ca2+/Mg2+-ATPase.
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Product Details
| Appearance |
Dark red to purple crystalline solid. |
|---|---|
| CAS |
11103-72-3 |
| Formula |
Cl6H42N14O2Ru3 . 4H2O |
| MI |
14: 8300 |
| MW |
786.4 . 72.1 |
| Purity |
≥90% (metals basis) |
| RTECS |
VM2656500 |
| Sequence |
[(NH3)5RuORu(NH3)4ORu(NH3)5]6+ 6Cl– |
| Solubility |
Soluble in water (10mg/ml) or ammonia. |
Handling & Storage
| Use/Stability |
As indicated on product label or CoA when stored as recommended. |
|---|---|
| Long Term Storage |
Ambient |
| Shipping |
Ambient Temperature |
| Regulatory Status |
RUO – Research Use Only |
|---|
- Kinesin light chain-4 depletion induces apoptosis of radioresistant cancer cells by mitochondrial dysfunction via calcium ion influx: J.H. Baek, et al.; Cell Death Dis. 9, 496 (2018), Abstract — Full Text
- Ruthenium red and capsazepine antinociceptive effect in formalin and capsaicin models of pain in mice: A.R. Santos & J.B. Calixto; Neurosci. Lett. 235, 73 (1997), Abstract
- Differential activation and desensitization of sensory neurons by resiniferatoxin: G. Acs, et al.; J. Neurosci. 17, 5622 (1997), Abstract
- Capsaicin-induced biphasic oxygen uptake in rat muscle: antagonism by capsazepine and ruthenium red provides further evidence for peripheral vanilloid receptor subtypes (VN1/VN2): C.D. Griffiths, et al.; Life Sci. 59, 105 (1996), Abstract
- Inhibition by capsazepine of resiniferatoxin- and capsaicin-induced contractions of guinea pig trachea: J.L. Ellis & B.J. Undem; J. Pharmacol. Exp. Ther. 268, 85 (1994), Abstract
- A comparison of capsazepine and ruthenium red as capsaicin antagonists in the rat isolated urinary bladder and vas deferens: C.A. Maggi, et al.; Br. J. Pharmacol. 108, 801 (1993), Abstract
- Capsazepine: a competitive antagonist of the sensory neurone excitant capsaicin: S. Bevan, et al.; Br. J. Pharmacol. 107, 544 (1992), Abstract
- Ruthenium red as a capsaicin antagonist: R. Amann & C.A. Maggi; Life Sci. 49, 849 (1991), Abstract
- Capsazepine, a novel capsaicin antagonist, selectively antagonises the effects of capsaicin in the mouse spinal cord in vitro: L. Urban and A. Dray; Neurosci. Lett. 134, 9 (1991), Abstract
- Interaction of ruthenium red with Ca2(+)-binding proteins: J.H. Charuk, et al.; Anal. Biochem. 188, 123 (1990), Abstract
- Capsaicin desensitization in vivo is inhibited by ruthenium red: R. Amann, et al.; Eur. J. Pharmacol. 186, 169 (1990), Abstract
- Effects of ruthenium red on activation of Ca2(+)-dependent cyclic nucleotide phosphodiesterase: H. Masuoka, et al.; BBRC 169, 315 (1990), Abstract
- The effects of ruthenium red on the response of guinea-pig ileum to capsaicin: L.A. Chahl; Eur. J. Pharmacol. 169, 241 (1989), Abstract
- Differential staining of biological structures by ruthenium red [published erratum appears in J. Microsc. 146, 333 (1987)]: M.G. Gutierrez-Gonzalvez, et al.; J. Microsc. 145, 333 (1987), Abstract
- Ruthenium red as a stain for electron microscopy. Some new aspects of its application and mode of action: R. Dierichs; Histochemistry 64, 171 (1979), Abstract
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