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Rufloxacin . hydrochloride

ALX-380-300

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Fluoroquinolone antibacterial agent

Fluoroquinolone antibacterial agent. Structurally similar to ofloxacin. Specific inhibitor of bacterial DNA gyrase (topoisomerase). Inhibits B-cell differentiation. Shows photosensitizing effects.

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Product Details

Alternative Name	6-Fluoro-2,3-dihydro-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzothiazine-6-carboxylic acid . hydrochloride, MF-934 . hydrochloride
Appearance	Off-white to light green crystalline solid.
CAS	106017-08-7
Couple Target	DNA gyrase
Couple Type	Inhibitor
Formula	C₁₇H₁₈FN₃O₃S . HCl
Identity	Identity determined by IR.
MI	14: 8294
MW	363.4 . 36.5
Purity	≥98% (Assay)
Solubility	Sparingly soluble in water; very slightly soluble in methanol; almost insoluble in chloroform or acetic acid.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Rufloxacin-induced photosensitization in yeast: A. Catalfo, et al.; Photochem. Photobiol. Sci. 6, 181 (2007), Abstract
Penetration of rufloxacin into the cerebrospinal fluid in patients with inflamed and uninflamed meninges: M.V. Moretti, et al.; Antimicrob. Agents Chemother. 44, 73 (2000), Abstract — Full Text
Molecular mechanisms of photosensitization induced by drugs. XII. Photochemistry and photosensitization of rufloxacin: an unusual photodegradation path for the antibacterials containing a fluoroquinolone-like chromophore: G. Condorelli, et al.; Photochem. Photobiol. 70, 280 (1999), Abstract
Comparison of the mechanism of action and resistance of two new fluoroquinolones, rufloxacin and MF961 with those of ofloxacin and fleroxacin in gram-negative and gram-positive bacteria: L.J. Piddock, et al.; J. Antimicrob. Chemother. 31, 855 (1993), Abstract
Rufloxacin once daily versus ofloxacin twice daily for treatment of complicated cystitis and upper urinary tract infections. Italian Multicentre UTI Rufloxacin Group: R. Mattina, et al.; Infection 21, 106 (1993), Abstract
Double-blind, comparative study of rufloxacin once daily versus amoxicillin three times a day in treatment of outpatients with exacerbations of chronic bronchitis: W. Klietmann, et al.; Antimicrob. Agents Chemother. 37, 2298 (1993), Abstract — Full Text
The in-vitro activity of two new quinolones: rufloxacin and MF 961: R. Wise, et al.; J. Antimicrob. Chemother. 29, 649 (1992), Abstract
Multiple-dose pharmacokinetics and safety of rufloxacin in normal volunteers: J.C. Kisicki, et al.; Antimicrob. Agents Chemother. 36, 1296 (1992), Abstract — Full Text
Effect of rufloxacin on in-vitro proliferation and differentiation of human mononuclear cells: S. Gollapudi, et al.; J. Antimicrob. Chemother. 29, 669 (1992), Abstract
Quinolonecarboxylic acids. 2. Synthesis and antibacterial evaluation of 7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benzothiazine-6-carboxylic acids: V. Cecchetti, et al.; J. Med. Chem. 30, 465 (1987), Abstract

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Rufloxacin . hydrochloride

ALX-380-300

Product Details

Handling & Storage

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