Carcinogenesis inhibitor
R,S-Sulforaphane is a synthetic version of the naturally occurring compound, R-sulforaphane, from Broccoli. It is a racemic mixture of both the R and S isomers.
Potent, selective inducer of phase II detoxification enzymes. Inhibits chemically induced mammary tumor formation in rats. Inhibits LPS-induced HMGB1 (high mobility group box 1) secretion.
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Product Details
| Alternative Name |
D,L-Sulforaphane, 1-Isothiocyanato-4-methylsulfinyl-butane |
|---|---|
| Appearance |
Slightly yellowish liquid. |
| CAS |
4478-93-7 (unspecified stereo) |
| Formula |
C6H11NOS2 |
| Identity |
Identity determined by 1H-NMR and MS. |
| MI |
14: 8962 |
| MW |
177.3 |
| Purity |
≥98% (UHPLC) |
| Solubility |
Soluble in methanol or DMSO. |
| Source |
Synthetic. |
Handling & Storage
| Use/Stability |
As indicated on product label or CoA when stored as recommended. |
|---|---|
| Long Term Storage |
-20°C |
| Shipping |
Ambient Temperature |
| Regulatory Status |
RUO – Research Use Only |
|---|
- Dietary Antioxidants Significantly Attenuate Hyperoxia-Induced Acute Inflammatory Lung Injury by Enhancing Macrophage Function via Reducing the Accumulation of Airway HMGB1: Patel, V., Dial, K., et al.; Int. J. Mol. Sci. 21, (2020), Abstract
- Free light chains injure proximal tubule cells through the STAT1/HMGB1/TLR axis: Upadhyay, R., Ying, W. Z., et al.; JCI Insight 5, (2020), Abstract
- Simultaneous quantification of sulforaphene and sulforaphane by reverse phase HPLC and their content in Raphanus sativus L. var. caudatus Alef extracts: S. Sangthong, et al.; Food. Chem. 201, 139 (2016), Application(s): Standard, Abstract
- Flavokawains A and B from kava (Piper methysticum) activate heat shock and antioxidant responses and protect against hydrogen peroxide-induced cell death in HepG2 hepatocytes: Pinner, K. D., Wales, C. T., et al.; Pharm. Biol. 54, 1503 (2016), Abstract
- Synergy between sulforaphane and selenium in protection against oxidative damage in colonic CCD841 cells: Y. Wang, et al.; Nutr. Res. 35, 610 (2015), Abstract
- 4-Methylthiobutyl isothiocyanate (Erucin) from rocket plant dichotomously affects the activity of human immunocompetent cells: C. Gründemann, et al.; Phytomedicine 22, 369 (2015), Application(s): Gas Chromatography – Mass Spectrometry , Abstract
- Protective effect of sulforaphane against oxidative stress: Recent advances: C.E. Guerrero-Beltran, et al.; Exp. Toxicol. Pathol. 64, 503 (2012), Abstract
- Sulforaphane targets pancreatic tumor-initiating cells by NF-{kappa}B-induced anti-apoptotic signaling: G. Kallifatidis, et al.; Gut 58, 949 (2009), Abstract
- The phase 2 enzyme inducers ethacrynic acid, DL-sulforaphane, and oltipraz inhibit lipopolysaccharide-induced high-mobility group box 1 secretion by RAW 264.7 cells: M.E. Killeen, et al.; J. Pharmacol. Exp. Ther. 316, 1070 (2006), Abstract
- A novel mechanism of chemoprotection by sulforaphane: inhibition of histone deacetylase: M.C. Myzak, et al.; Cancer Res. 64, 5767 (2004), Abstract — Full Text
- Anticarcinogenic activities of sulforaphane and structurally related synthetic norbornyl isothiocyanates: Y. Zhang, et al.; PNAS 91, 3147 (1994), Abstract — Full Text
- A major inducer of anticarcinogenic protective enzymes from broccoli: isolation and elucidation of structure: Y. Zhang, et al.; PNAS 89, 2399 (1992), Abstract — Full Text
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| Purity | ≥98% (HPLC) |
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Last modified: May 29, 2024
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