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R,S-Sulforaphane

ALX-350-232

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Carcinogenesis inhibitor

R,S-Sulforaphane is a synthetic version of the naturally occurring compound, R-sulforaphane, from Broccoli. It is a racemic mixture of both the R and S isomers.
Potent, selective inducer of phase II detoxification enzymes. Inhibits chemically induced mammary tumor formation in rats. Inhibits LPS-induced HMGB1 (high mobility group box 1) secretion.

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Product Details

Alternative Name	D,L-Sulforaphane, 1-Isothiocyanato-4-methylsulfinyl-butane
Appearance	Slightly yellowish liquid.
CAS	4478-93-7 (unspecified stereo)
Formula	C₆H₁₁NOS₂
Identity	Identity determined by 1H-NMR and MS.
MI	14: 8962
MW	177.3
Purity	≥98% (UHPLC)
Solubility	Soluble in methanol or DMSO.
Source	Synthetic.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Dietary Antioxidants Significantly Attenuate Hyperoxia-Induced Acute Inflammatory Lung Injury by Enhancing Macrophage Function via Reducing the Accumulation of Airway HMGB1: Patel, V., Dial, K., et al.; Int. J. Mol. Sci. 21, (2020), Abstract
Free light chains injure proximal tubule cells through the STAT1/HMGB1/TLR axis: Upadhyay, R., Ying, W. Z., et al.; JCI Insight 5, (2020), Abstract
Simultaneous quantification of sulforaphene and sulforaphane by reverse phase HPLC and their content in Raphanus sativus L. var. caudatus Alef extracts: S. Sangthong, et al.; Food. Chem. 201, 139 (2016), Application(s): Standard, Abstract
Flavokawains A and B from kava (Piper methysticum) activate heat shock and antioxidant responses and protect against hydrogen peroxide-induced cell death in HepG2 hepatocytes: Pinner, K. D., Wales, C. T., et al.; Pharm. Biol. 54, 1503 (2016), Abstract
Synergy between sulforaphane and selenium in protection against oxidative damage in colonic CCD841 cells: Y. Wang, et al.; Nutr. Res. 35, 610 (2015), Abstract
4-Methylthiobutyl isothiocyanate (Erucin) from rocket plant dichotomously affects the activity of human immunocompetent cells: C. Gründemann, et al.; Phytomedicine 22, 369 (2015), Application(s): Gas Chromatography – Mass Spectrometry , Abstract
Protective effect of sulforaphane against oxidative stress: Recent advances: C.E. Guerrero-Beltran, et al.; Exp. Toxicol. Pathol. 64, 503 (2012), Abstract
Sulforaphane targets pancreatic tumor-initiating cells by NF-{kappa}B-induced anti-apoptotic signaling: G. Kallifatidis, et al.; Gut 58, 949 (2009), Abstract
The phase 2 enzyme inducers ethacrynic acid, DL-sulforaphane, and oltipraz inhibit lipopolysaccharide-induced high-mobility group box 1 secretion by RAW 264.7 cells: M.E. Killeen, et al.; J. Pharmacol. Exp. Ther. 316, 1070 (2006), Abstract
A novel mechanism of chemoprotection by sulforaphane: inhibition of histone deacetylase: M.C. Myzak, et al.; Cancer Res. 64, 5767 (2004), Abstract — Full Text

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R,S-Sulforaphane

ALX-350-232

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