RS-1

• GMP format available

RS-1 is a cell-permeable sulfonamido-benzamide-based allosteric regulator. It enhances the DNA binding and recombinase activities of the human homologous recombination protein RAD51 by stabilizing its active conformation without affecting its ATP hydrolysis activity.

Key features and applications include:

• DNA Repair Studies: RS-1 promotes the formation of active RAD51 filaments on single-stranded DNA (ssDNA), enhancing homologous recombination efficiency.
• Genome Editing: It significantly increases the efficiency of CRISPR-Cas9 and TALEN-mediated genome editing by enhancing homology-directed repair (HDR).
• Cancer Research: RS-1 has been shown to increase the resistance of primary human neonatal dermal fibroblasts to cisplatin-induced cell death.

Relevant disease states include:

• Cancer: RS-1 has shown potential in promoting antitumor responses by enhancing DNA repair mechanisms, making it relevant for research into various cancers.
• Genetic Disorders: Its role in enhancing HDR makes it useful in studying genetic disorders where precise gene correction is needed.