Rp-cAMPS

BML-CN135

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PKA inhibitor

Rp-cAMPS is a potent and specific competitive inhibitor of the activation of cAMP-dependent protein kinases by cAMP (IC₅₀=4.9 µM) . Its cell permeability and complete resistance to cyclic nucleotide phosphodiesterases make it a unique tool for studying cAMP-dependent signaling. Significantly more lipophilc as compared to cAMP and thus membrane permeable in many biological systems. This product is not sterile.

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Product Details

Appearance	Clear film.
CAS	151837-09-1
Couple Target	PKA
Couple Type	Inhibitor
Formula	C₁₀H₁₁N₅O₅PS . C₆H₁₆N
MW	446.5
Purity	≥98% (HPLC)
Solubility	Soluble in water (25mg/ml), aqueous buffers, methanol, 100% ethanol or DMSO.
Source	Synthetic.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Store, as supplied, at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Age-Related Increases in PDE11A4 Protein Expression Trigger Liquid-Liquid Phase Separation (LLPS) of the Enzyme That Can Be Reversed by PDE11A4 Small Molecule Inhibitors: Amurrio, E., Patel, J. H., et al.; Cells 14, 897 (2025), Abstract
Disruption of Mitochondrial-associated ER membranes by HIV-1 tat protein contributes to premature brain aging: S.P. Arjona, et al.; CNS Neurosci. Ther. 29, 365 (2023), Abstract
PINK1-induced phosphorylation of mitofusin 2 at serine 442 causes its proteasomal degradation and promotes cell proliferation in lung cancer and pulmonary arterial hypertension: Dasgupta, A., Chen, K. H., et al.; FASEB J. 35, e21771 (2021), Abstract
Biased signaling initiated by agouti-related peptide through human melanocortin-3 and − 4 receptors: Z. Yang & Y.X. Tao; Biochim. Biophys. Acta 1862, 1485 (2016), Application(s): Cell culture, Abstract
Proangiogenic Effect of TSH in Human Microvascular Endothelial Cells through Its Membrane Receptor: S. Balzan, et al.; J. Clin. Endocrinol. Metab. 97, 1763 (2012), Application(s): Inhibition of cAMP signaling in HMEC-1 and HMVEC cell culture, Abstract
Effects of protein kinase A inhibitor and activator on rewarding effects of SKF-82958 microinjected into nucleus accumbens shell of ad libitum fed and food-restricted rats: de Vaca, S. C., Peng, X. X., et al.; Psychopharmacology (Berl.) 221, 589 (2012), Abstract
Stimulation of the ERK pathway by GTP-loaded Rap1 requires the concomitant activation of Ras, protein kinase C, and protein kinase A in neuronal cells: T. Bouschet et al.; J. Biol. Chem. 278, 4778 (2003), Abstract
Cell-permeable non-hydrolyzable cAMP derivatives as tools for analysis of signaling pathways controlling gene regulation in Dictyostelium: P. Schaap et al.; J. Biol. Chem. 268, 6323 (1993), Abstract
Regulation of kainate receptors by cAMP-dependent protein kinase and phosphatases: L.Y. Wang et al.; Science 253, 1132 (1991), Abstract
Probing the cyclic nucleotide binding sites of cAMP-dependent protein kinases I and II with analogs of adenosine 3’,5’-cyclic phosphorothioates: W.R.G. Dostmann et al.; J. Biol. Chem. 265, 10484 (1990), Abstract

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Rp-cAMPS

BML-CN135

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