Home Shop Rp-8-pCPT-cGMPS . sodium salt

Rp-8-pCPT-cGMPS . sodium salt

BML-CN206

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PKG inhibitor

A cell-permeable cGMP antagonist which is resistant to hydrolysis by cyclic nucleotide phosphodiesterases (K_i=0.5 µM). No metabolic side effects. Significantly more lipophilic and membrane permeant as compared to Rp-cGMPS (Prod. No. ALX-480-072) or Rp-8-Br-cGMPS (Prod. No. BML-CN216)

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Product Details

Appearance	White solid.
CAS	153660-04-9
Couple Target	PKG
Couple Type	Inhibitor
Formula	C₁₆H₁₄N₅O₆PS₂Cl . Na
MW	525.9
Purity	≥98% (HPLC)
Solubility	Soluble in water (25 mg/ml).

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Store, as supplied, at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Green tea catechins enhance norepinephrine-induced lipolysis via a protein kinase A-dependent pathway in adipocytes: S. Chen, et al.; Biochem. Biophys. Res. Commun. 461, 1 (2015), Application(s): Cell Culture, Abstract
Differential activation of natriuretic peptide receptors modulates cardiomyocyte proliferation during development: Becker, J. R., Chatterjee, S., et al.; Development 141, 335 (2014), Abstract
Involvement of a NO-cyclic GMP-PKG signaling pathway in nitrous oxide-induced antinociception in mice: Zhang, Y., Quock, L. P., et al.; Eur. J. Pharmacol. 654, 249 (2011), Abstract
The acute antinociceptive effect of HBO₂ is mediated by a NO-cyclic GMP-PKG-KATP channel pathway in mice: Quock, L. P., Zhang, Y., et al.; Brain Res. 1368, 102 (2011), Abstract
Nitric oxide induces airway smooth muscle cell relaxation by decreasing the frequency of agonist-induced Ca2+ oscillations: Perez-Zoghbi, J. F., Bai, Y., et al.; J. Gen. Physiol. 135, 247 (2010), Abstract
Antagonists of cyclic nucleotide-gated channels and molecular mapping of their site of action: R.H. Kramer & G.R. Tibbs; J. Neurosci. 16, 1285 (1996), Abstract
The type II isoform of cGMP-dependent protein kinase is dimeric and possesses regulatory and catalytic properties distinct from the type I isoforms: D.M. Gamm et al.; J Biol Chem 270, 27380 (1995), Abstract
(Rp)-8-pCPT-cGMPS, a novel cGMP-dependent protein kinase inhibitor: E. Butt et al.; Eur. J. Pharmacol. 269, 265 (1994), Abstract

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Rp-8-pCPT-cGMPS . sodium salt

BML-CN206

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

Certificate of Analysis

SDS

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