Rp-8-Br-MB-cAMPS

Rp-8-Br-MB-cAMPS is a lipophilic precursor of the cyclic AMP antagonist Rp-8-Br-cAMPS (Prod. No. BLG-B001). The butyryl group masks the polar 2′ hydroxyl group and facilitate membrane permeability. During metabolic activation by intracellular esterases the inhibitor and butyrate are released. As observed with dibutyryl cAMP, release of butyrate can already start in the medium if it contains serum esterases. Please note that butyrate can have its own biochemical effects, therefore a control experiment with sodium butyrate is necessary.
Significantly more lipophilic and membrane permeant compared to Rp-8-Br-cAMPS.