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Rp-8-Br-cGMPS

BML-CN216

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PKG inhibitor

Cell-permeable, phosphodiesterase-resistant cGMP antagonist. Reversed NO stimulation of random migration in rabbit neutrophils. Used at 30µM to cometively inhibit 8-Br-cGMP relaxation of rabbit aortas. The product is not sterile. Resistant to nucleotide-dependent phosphodiesterases; no metabolic side effects. Significantly more lipophilic and membrane permeant as compared to cyclic GMP or Rp-cGMPS.

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Product Details

Appearance	White lyophilized powder.
CAS	150418-07-8
Couple Target	PKG
Couple Type	Inhibitor
Formula	C₁₀H₁₀BrN₅O₆PS . Na
MW	462.2
Purity	≥98% (HPLC)
Solubility	Soluble in water (25mg/ml).

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Store, as supplied, at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Cyclic nucleotide phosphodiesterase 1 regulates lysosome-dependent type I collagen protein degradation in vascular smooth muscle cells: Y. Cay, et al.; Arterioscler. Thromb. Vasc. Biol. 31, 616 (2011), Abstract — Full Text
Modulation of neutrophil migration by exogenous gaseous nitric oxide: B.E. Van Uffelen, et al.; J. Leukoc. Biol. 60, 94 (1996), Abstract
Rp-8-Br-guanosine-3’,5’-cyclic monophosphorothioate inhibits relaxation elicited by nitroglycerin in rabbit aorta: M. Nakazawa & S. Imai; Eur. J. Pharmacol. 253, 179 (1994), Abstract
Role of guanylyl cyclase and cGMP-dependent protein kinase in long-term potentiation: M. Zhuo, et al.; Nature 368, 635 (1994), Abstract
Nitric oxide regulates luteinizing hormone-releasing hormone secretion: M. Moretto, et al.; Endocrinology 133, 2399 (1993), Abstract

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Rp-8-Br-cGMPS

BML-CN216

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

Certificate of Analysis

SDS

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