Rp-8-AET-cGMPS-Agarose

The metabolically stable protein kinase G inhibitor Rp-cGMPS immobilized on agarose by an aminoethylthio spacer attached to position 8 of the ligand. Its reduced binding affinity towards protein kinase G compared to cGMP should result in milder desorption conditions in affinity chromatography. The gel can be used for affinity chromatography of various cyclic nucleotide-responsive proteins such as protein kinases, phosphodiesterases and others. Gels with the corresponding Sp-isomer (Sp-8-AET-cGMPS-Agarose (Prod. No. BLG-A010)) and the parent cyclic phosphate (8-AET-cGMP-Agarose (Prod. No. BLG-A019)) are also available.