Rotenone

ALX-350-360

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Insecticide. Inhibitor of mitochondrial electron transport. Specifically inhibits NAD-linked substrate oxidation at the oxygen side of NADH dehydrogenase (EC₅₀=10pmol/mg). Inhibits mammalian cell proliferation by inhibiting microtubule assembly through tubulin binding. Can inhibit mitochondrial swelling and cytochrome c release induced by N-methyl-4-phenylpyridinium.

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Product Details

Appearance	White to off-white solid.
CAS	83-79-4
Couple Target	Mitochondrial complex
Couple Type	Inhibitor
Formula	C₂₃H₂₂O₆
MI	14: 8271
MW	394.4
Purity	≥97% (UHPLC)
RTECS	DJ2800000
Solubility	Soluble in DMSO or 100% ethanol; slightly soluble in water.
Source	Isolated from Lonchocarpus sp. or Derris sp.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Handling	Protect from light.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

STAT3 modulates CD4+ T mitochondrial dynamics and function in aging: Zukowski, E., Sannella, M., et al.; Aging Cell 22, e13996 (2023), Abstract
Kynurenine attenuates mitochondrial depolarization and neuronal cell death induced by rotenone exposure independently of AhR-mediated parkin induction in SH-SY5Y differentiated cells: R.G. Aguilar, et al.; Neurotoxicology 99, 282 (2023), Abstract
NF-κB–Inducing Kinase Governs the Mitochondrial Respiratory Capacity, Differentiation, and Inflammatory Status of Innate Immune Cells: J.N. Keeney, et al.; J. Immunol. 210, 1123 (2023), Abstract
Carbon Monoxide Releasing Molecule-3 Enhances Heme Oxygenase-1 Induction via ROS-Dependent FoxO1 and Nrf2 in Brain Astrocytes: C. C. Lin, et al.; Oxid. Med. Cell. Longev. 2021, 5521196 (2021), Abstract
CYP27A1-dependent anti-melanoma activity of limonoid natural products targets mitochondrial metabolism: Cho, H., Shen, Q., et al.; Cell Chem. Biol. 28, 1407 (2021), Abstract
Loss of Ubiquitin Carboxy-Terminal Hydrolase L1 Impairs Long-Term Differentiation Competence and Metabolic Regulation in Murine Spermatogonial Stem Cells: W.F. Alpaugh, et al.; Cells 10, 2265 (2021), Abstract
Unique metabolic phenotype and its transition during maturation of juvenile male germ cells: A.L. Voigt, et al.; FASEB J. 15, 21513 (2021), Abstract
Five months of voluntary wheel running downregulates skeletal muscle LINE-1 gene expression in rats: Romero, M. A., Mumford, P. W., et al.; Am. J. Physiol. Cell Physiol. 317, C1313 (2019), Abstract
Reciprocal effects of rab7 deletion in activated and neglected T cells: Roy, S. G., Stevens, M. W., et al.; Autophagy 9, 1009 (2013), Abstract
Protection by the NDI1 Gene against Neurodegeneration in a Rotenone Rat Model of Parkinson’s Disease: M. Marella, et al.; PLoS ONE 3, e1433 (2008), Abstract — Full Text

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Rotenone

ALX-350-360

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