RORγ (h) Reporter Assay System

This nuclear receptor assay system utilizes proprietary non-human mammalian cells engineered to provide high-level expression of a hybrid form of the Human RAR-related Orphan Receptor Gamma. The N-terminal DNA binding domains (DBD) of the native RORγ and RORγt receptors have been substituted with that of the yeast GAL4-DBD. Hence, the GAL4-RORγ hybrid receptor expressed in these reporter cells will not discern any functional differences that may exist between the native isoform 1 and isoform 2 receptors. The principle application of this reporter assay system is in the screening of test samples to quantify inverse-agonist or antagonist activities that they may exert against human RORγ.